TY - GEN
T1 - Knowledge management on the novel LAGE-Like GlcNAc-transferase protein family
AU - Hwa, Kuo Yuan
AU - Lin, Wan Man
AU - Lee, Chueh Pai
AU - Chen, Mei Yu
PY - 2009
Y1 - 2009
N2 - To study a novel protein family requires a biologist to understand many different types of information. Moreover, the speed of discovery in biology has been expanding exponentially. And, the public knowledge management platforms are not customerized to a research project. It is often cumbersome. To overcome these obstacles, we have set up a knowledge management platform by integrating several databases. Particularly, we have constructed a knowledge management platform on the novel LARGE-liked glycosyltransferases family. The predicted protein structure of a LARGE protein family member contains an N-terminal cytoplasmic domain, a transmembrane region, a coiled-coil motif and a putative catalytic domain with the conserved DXD motif and a conserved protein structural domain, as previously described. Firstly, we have developed workflow to identify the members of the LARGE-liked protein family. We then have integrated DNA sequence, protein sequence, protein domain, protein family based on the CAZY databank, human and animal disease information and references into one knowledge management platform for studying diseases.
AB - To study a novel protein family requires a biologist to understand many different types of information. Moreover, the speed of discovery in biology has been expanding exponentially. And, the public knowledge management platforms are not customerized to a research project. It is often cumbersome. To overcome these obstacles, we have set up a knowledge management platform by integrating several databases. Particularly, we have constructed a knowledge management platform on the novel LARGE-liked glycosyltransferases family. The predicted protein structure of a LARGE protein family member contains an N-terminal cytoplasmic domain, a transmembrane region, a coiled-coil motif and a putative catalytic domain with the conserved DXD motif and a conserved protein structural domain, as previously described. Firstly, we have developed workflow to identify the members of the LARGE-liked protein family. We then have integrated DNA sequence, protein sequence, protein domain, protein family based on the CAZY databank, human and animal disease information and references into one knowledge management platform for studying diseases.
KW - Knowledge Management
KW - LARGE-liked GlcNAcTtransferase
KW - Protein family
UR - http://www.scopus.com/inward/record.url?scp=78249231415&partnerID=8YFLogxK
U2 - 10.1007/978-3-642-10616-3_19
DO - 10.1007/978-3-642-10616-3_19
M3 - Conference contribution
AN - SCOPUS:78249231415
SN - 3642106153
SN - 9783642106156
T3 - Communications in Computer and Information Science
SP - 141
EP - 145
BT - Bio-Science and Bio-Technology - International Conference, BSBT 2009. Held as Part of the Future Generation Information Technology Conference, FGIT 2009, Proceedings
T2 - International Conference on Bio-Science and Bio-Technology, BSBT 2009. Held as Part of the Future Generation Information Technology Conference, FGIT 2009
Y2 - 10 December 2009 through 12 December 2009
ER -
