Kidney Function Trajectory within Six Months after Acute Kidney Injury Inpatient Care and Subsequent Adverse Kidney Outcomes: A Retrospective Cohort Study

You Lin Tain, Chien-Liang Liu, Hsiao-Ching Kuo, Chien-Ning Hsu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Timing and extent of kidney function recovery after an acute kidney injury (AKI) episode are associated with chronic kidney disease onset and progression. This study aimed to categorize AKI recovery patterns within 6 months after index hospital discharge and associate them with kidney outcomes. This was a retrospective cohort study of 234,867 patients, hospitalized between 2010 and 2017, and classified as AKI or no AKI. Kidney function recovery from pre-hospitalization baseline within 1.5× serum creatinine (SCr) were evaluated at 3 and 6 months after hospital discharge and categorized as persistent non-recovery (PNR: SCr not recovered at 3 and 6 months), non-recovery (NR: SCr not recovered at 6 months), and recovery (SCr recovered at 6 months). A composite of incident chronic kidney disease, kidney replacement therapy, and estimated glomerular filtration rate reduction >30% from baseline and
Original languageAmerican English
Article number1606
JournalJournal of Personalized Medicine
Volume12
Issue number10
DOIs
StatePublished - 29 Sep 2022

Keywords

  • acute kidney injury
  • kidney function recovery
  • chronic dialysis
  • end stage kidney disease
  • kidney function trajectory

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