Johnson-Kendall-Roberts theory applied to living cells

Y. S. Chu*, S. Dufour, J. P. Thiery, E. Ferez, F. Pincet

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

The Johnson-Kendall-Roberts (JKR) theory is an accurate model for of soft deformable materials with strong adhesion energies. Little is known about the validity of this theory on complex systems such as living cells. We have addressed this question using a depletion controlled cell adhesion and measured the force necessary to separate the cells with a micropipette technique. We show that the cytoskeleton can provide the cells with a 3D structure that is sufficiently elastic and has a sufficiently low deformability for JICR theory to be valid. When the cytoskeleton is disrupted, JKR theory is no longer applicable.

Original languageEnglish
Title of host publication2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings
EditorsM. Laudon, B. Romanowicz
Pages560-562
Number of pages3
StatePublished - May 2005
Event2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 - Anaheim, CA, United States
Duration: 8 May 200512 May 2005

Publication series

Name2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings

Conference

Conference2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005
Country/TerritoryUnited States
CityAnaheim, CA
Period8/05/0512/05/05

Keywords

  • Cell adhesion
  • Cytoskeleton
  • Depletion forces
  • Elastic shells
  • Elastic spheres

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