Involvement of EGFR-AKT signaling in hemin-induced neurotoxicity

Keyphrases

• Neurotoxicity 100%
• Epithelial Growth Factor Receptor 100%
• Hemin 100%
• AKT Pathway 100%
• Afatinib 60%
• Intracerebral Hemorrhage 40%
• Incubation 20%
• Co-treatment 20%
• Neuronal Death 20%
• Heme oxygenase-1 (HO-1) 20%
• Pathophysiology 10%
• Co-incubation 10%
• Culture Media 10%
• Glutathione 10%
• Neurite 10%
• Programmed Cell Death 10%
• Receptor Tyrosine Kinase 10%
• Heme 10%
• Akt Activation 10%
• Hemoglobin 10%
• NO Production 10%
• Immunoreactivity 10%
• Neuroinflammation 10%
• Tumor Necrosis Factor-α 10%
• Neurodegeneration 10%
• AKT1 10%
• Cyclooxygenase-2 10%
• Primary Cortical Neurons 10%
• Bleeding 10%
• Growth Factor Receptor Tyrosine Kinase 10%
• Western Blot Assay 10%
• Ischemic Stroke 10%
• Neuropathology 10%
• Lactate Dehydrogenase Assay 10%
• Druggable Targets 10%
• Epithelial Growth Factor Receptor Tyrosine Kinase Inhibitor 10%
• Inflammatory Biomarkers 10%
• Necroptosis 10%
• EGFR Phosphorylation 10%
• Receptor-interacting Protein Kinase 3 (RIPK3) 10%
• Ferroptosis 10%
• Hydroperoxidases 10%

Pharmacology, Toxicology and Pharmaceutical Science

• Neurotoxicity 100%
• Growth Factor Receptor 100%
• Protein Kinase B 100%
• Hemin 100%
• Afatinib 60%
• Brain Hemorrhage 40%
• Protein Tyrosine Kinase 20%
• Biological Marker 20%
• Heme Oxygenase 1 20%
• Pathophysiology 10%
• Glutathione 10%
• Western Blot 10%
• Receptor 10%
• Protein Tyrosine Kinase Inhibitor 10%
• Tumor Necrosis Factor 10%
• Epidermal Growth Factor Receptor 10%
• Nervous System Inflammation 10%
• Cyclooxygenase 2 10%
• Nerve Degeneration 10%
• Brain Ischemia 10%
• Lactate Dehydrogenase 10%
• Bleeding 10%
• Synapsin II 10%
• Heme 10%
• Ferroptosis 10%

Neuroscience

• Protein Kinase B 100%
• Neurotoxicity 100%
• Growth Factor Receptor 100%
• Hemin 100%
• Afatinib 60%
• Cerebral Hemorrhage 40%
• Neuronal Cell Death 20%
• Heme Oxygenase 1 20%
• Western Blot 10%
• Neurite 10%
• Neurodegeneration 10%
• Brain Ischemia 10%
• Epidermal Growth Factor Receptor 10%
• Necrosis 10%
• Cell Death 10%
• Receptor Tyrosine Kinase 10%
• Glutathione 10%
• Lactate Dehydrogenase 10%
• Cyclooxygenase 2 10%
• Prothrombin 10%
• Receptor Tyrosine Kinase Inhibitors 10%
• Synapsin II 10%
• Heme 10%
• Necroptosis 10%
• Receptor 10%
• Ferroptosis 10%