Intrastriatal transplantation of Sertoli cells may improve amphetamine- induced rotation and tyrosine hydroxylase immunoreactivity of the striatum in hemiparkinsonian rats

Hwan Wun Liu; Ya Jane Kuang; Jiahn Chun Wu; Kuo Hsing Ma; Shwun De Wang; Jiang Chuan Liu

doi:10.1016/S0006-8993(99)01656-X

Intrastriatal transplantation of Sertoli cells may improve amphetamine- induced rotation and tyrosine hydroxylase immunoreactivity of the striatum in hemiparkinsonian rats

Hwan Wun Liu^*, Ya Jane Kuang, Jiahn Chun Wu, Kuo Hsing Ma, Shwun De Wang, Jiang Chuan Liu

^*Corresponding author for this work

Department of Anatomy and Cell Biology

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

This study investigated survival and neurotrophic effects of Sertoli cells transplanted in the striatum of 6-hydroxydopamine (6-OHDA)-induced hemiparkinsonian rats. Primary cultures of Sertoli cells were established from 3-week old rats and characterized by associated marker, placental cadherin (P-cadherin). Two months after transplantation, amphetamine-induced rotations of rats transplanted with Sertoli cells were significantly lower than those of control rats. However, restoration of tyrosine hydroxylase (TH) immunoreactivity and Sertoli cells that expressed P-cadherin were only found in the striatum of the rat that showed full recovery from amphetamine-induced rotation 3 months after transplantation without immunosuppression. These results suggest that Sertoli cells transplanted in striatum of hemiparkinsonian rats may survive for at least 3 months, and improve amphetamine-induced rotation and restore TH immunoreactivity.

Original language	English
Pages (from-to)	227-233
Number of pages	7
Journal	Brain Research
Volume	838
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(99)01656-X
State	Published - 14 Aug 1999

Keywords

Parkinson's disease
Sertoli cell
Striatum
Substantia nigra
Transplantation

Access to Document

10.1016/S0006-8993(99)01656-X

Cite this

@article{4d4a5b6dbb0b4e4ab13f8e563f3e0623,

title = "Intrastriatal transplantation of Sertoli cells may improve amphetamine- induced rotation and tyrosine hydroxylase immunoreactivity of the striatum in hemiparkinsonian rats",

abstract = "This study investigated survival and neurotrophic effects of Sertoli cells transplanted in the striatum of 6-hydroxydopamine (6-OHDA)-induced hemiparkinsonian rats. Primary cultures of Sertoli cells were established from 3-week old rats and characterized by associated marker, placental cadherin (P-cadherin). Two months after transplantation, amphetamine-induced rotations of rats transplanted with Sertoli cells were significantly lower than those of control rats. However, restoration of tyrosine hydroxylase (TH) immunoreactivity and Sertoli cells that expressed P-cadherin were only found in the striatum of the rat that showed full recovery from amphetamine-induced rotation 3 months after transplantation without immunosuppression. These results suggest that Sertoli cells transplanted in striatum of hemiparkinsonian rats may survive for at least 3 months, and improve amphetamine-induced rotation and restore TH immunoreactivity.",

keywords = "Parkinson's disease, Sertoli cell, Striatum, Substantia nigra, Transplantation",

author = "Liu, {Hwan Wun} and Kuang, {Ya Jane} and Wu, {Jiahn Chun} and Ma, {Kuo Hsing} and Wang, {Shwun De} and Liu, {Jiang Chuan}",

note = "Funding Information: Authors are grateful to Professor Marion Murray of Department of Neurobiology and Anatomy, Allegheny University of the Health Sciences, Philadelphia, PA, and Dr. Cesario V. Borlongan of Cellular Neurophysiology Section, National Institute on Drug Abuse, Baltimore, MD, USA, for their generous help in preparing this paper. This study is supported by grants (NSC 86-2314-B016-066-M20 and NSC 87-2314-B016-066-M20) from National Science Council of Republic of China. ",

year = "1999",

month = aug,

day = "14",

doi = "10.1016/S0006-8993(99)01656-X",

language = "English",

volume = "838",

pages = "227--233",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier",

number = "1-2",

}

TY - JOUR

T1 - Intrastriatal transplantation of Sertoli cells may improve amphetamine- induced rotation and tyrosine hydroxylase immunoreactivity of the striatum in hemiparkinsonian rats

AU - Liu, Hwan Wun

AU - Kuang, Ya Jane

AU - Wu, Jiahn Chun

AU - Ma, Kuo Hsing

AU - Wang, Shwun De

AU - Liu, Jiang Chuan

N1 - Funding Information: Authors are grateful to Professor Marion Murray of Department of Neurobiology and Anatomy, Allegheny University of the Health Sciences, Philadelphia, PA, and Dr. Cesario V. Borlongan of Cellular Neurophysiology Section, National Institute on Drug Abuse, Baltimore, MD, USA, for their generous help in preparing this paper. This study is supported by grants (NSC 86-2314-B016-066-M20 and NSC 87-2314-B016-066-M20) from National Science Council of Republic of China.

PY - 1999/8/14

Y1 - 1999/8/14

N2 - This study investigated survival and neurotrophic effects of Sertoli cells transplanted in the striatum of 6-hydroxydopamine (6-OHDA)-induced hemiparkinsonian rats. Primary cultures of Sertoli cells were established from 3-week old rats and characterized by associated marker, placental cadherin (P-cadherin). Two months after transplantation, amphetamine-induced rotations of rats transplanted with Sertoli cells were significantly lower than those of control rats. However, restoration of tyrosine hydroxylase (TH) immunoreactivity and Sertoli cells that expressed P-cadherin were only found in the striatum of the rat that showed full recovery from amphetamine-induced rotation 3 months after transplantation without immunosuppression. These results suggest that Sertoli cells transplanted in striatum of hemiparkinsonian rats may survive for at least 3 months, and improve amphetamine-induced rotation and restore TH immunoreactivity.

AB - This study investigated survival and neurotrophic effects of Sertoli cells transplanted in the striatum of 6-hydroxydopamine (6-OHDA)-induced hemiparkinsonian rats. Primary cultures of Sertoli cells were established from 3-week old rats and characterized by associated marker, placental cadherin (P-cadherin). Two months after transplantation, amphetamine-induced rotations of rats transplanted with Sertoli cells were significantly lower than those of control rats. However, restoration of tyrosine hydroxylase (TH) immunoreactivity and Sertoli cells that expressed P-cadherin were only found in the striatum of the rat that showed full recovery from amphetamine-induced rotation 3 months after transplantation without immunosuppression. These results suggest that Sertoli cells transplanted in striatum of hemiparkinsonian rats may survive for at least 3 months, and improve amphetamine-induced rotation and restore TH immunoreactivity.

KW - Parkinson's disease

KW - Sertoli cell

KW - Striatum

KW - Substantia nigra

KW - Transplantation

UR - http://www.scopus.com/inward/record.url?scp=0033554227&partnerID=8YFLogxK

U2 - 10.1016/S0006-8993(99)01656-X

DO - 10.1016/S0006-8993(99)01656-X

M3 - Article

C2 - 10446339

AN - SCOPUS:0033554227

SN - 0006-8993

VL - 838

SP - 227

EP - 233

JO - Brain Research

JF - Brain Research

IS - 1-2

ER -

Intrastriatal transplantation of Sertoli cells may improve amphetamine- induced rotation and tyrosine hydroxylase immunoreactivity of the striatum in hemiparkinsonian rats

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this