Intraoperative application of optical coherence tomography for lung tumor

Hung Chang Liu, Miao Hui Lin, Ching Heng Ting, Yi Min Wang, Chia Wei Sun*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


On-site instant determination of benign or malignant tumors for deciding the types of resection is crucial during pulmonary surgery. We designed a portable spectral-domain optical coherence tomography (SD-OCT) system to do real-time scanning intraoperatively for the distinction of fresh tumor specimens in the lung. A total of 12 ex vivo lung specimens from six patients were enrolled. Three patients were diagnosed with invasive adenocarcinoma (IA), while the others were benign. After OCT-imaged reconstruction, we compared the qualitative morphology of OCT and histology among malignant, benign, and normal tissues. In addition, through analysis of the quantitative data, a discrete difference in optical attenuation coefficients around the junctional surface was shown by our data processing. This study demonstrated a feasible OCT-assisted resection guide by a rapid on-site tumor diagnosis. The results indicate that future deep learning of OCT-captured image systems able to improve diagnostic and therapeutic efficiency is warranted.

Original languageEnglish
Article numbere202200344
JournalJournal of Biophotonics
Issue number6
StatePublished - Jun 2023


  • attenuation coefficient
  • lung surgery
  • optical biopsy intraoperatively
  • optical coherence tomography (OCT)


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