Interplay of immunometabolism and epithelial–mesenchymal transition in the tumor microenvironment

Ming Yu Chou, Muh Hwa Yang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


Epithelial–mesenchymal transition (EMT) and metabolic reprogramming in cancer cells are the key hallmarks of tumor metastasis. Since the relationship between the two has been well studied, researchers have gained increasing interest in the interplay of cancer cell EMT and immune metabolic changes. Whether the mutual influences between them could provide novel explanations for immune surveillance during metastasis is worth understanding. Here, we review the role of immunometabolism in the regulatory loop between tumor-infiltrating immune cells and EMT. We also discuss the challenges and perspectives of targeting immunometabolism in cancer treatment.

Original languageEnglish
Article number9878
JournalInternational Journal Of Molecular Sciences
Issue number18
StatePublished - Sep 2021


  • Epithelial–mesenchymal transition
  • Immunometabolism
  • Tumor microenvironment


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