TY - GEN
T1 - Integration of fluctuation spectroscopy into a microfluidic platform for novel cellular viscoelastic measurement
AU - Ito, Hiroaki
AU - Tsai, Chia-Hung
AU - Kaneko, Makoto
N1 - Publisher Copyright:
© 2018 IEEE.
PY - 2018/4/24
Y1 - 2018/4/24
N2 - This paper demonstrates the integration of fluctuation spectroscopy into a microfluidic platform, which enables a novel high-throughput measurement of viscoelastic parameters for μm-sized soft objects such as red blood cells (RBCs) flowing in a microfluidic channel. Utilizing high-speed/precise feedback position control of a RBC inside a narrow microfluidic channel, we successfully performed fluctuation spectroscopy, which is called flicker spectroscopy, sequentially combined with the conventional constriction-passage method. The result shows implicit correlations between mechanical parameters obtained from these two different measurements, providing indications to full information of viscosity and elasticity of a RBC.
AB - This paper demonstrates the integration of fluctuation spectroscopy into a microfluidic platform, which enables a novel high-throughput measurement of viscoelastic parameters for μm-sized soft objects such as red blood cells (RBCs) flowing in a microfluidic channel. Utilizing high-speed/precise feedback position control of a RBC inside a narrow microfluidic channel, we successfully performed fluctuation spectroscopy, which is called flicker spectroscopy, sequentially combined with the conventional constriction-passage method. The result shows implicit correlations between mechanical parameters obtained from these two different measurements, providing indications to full information of viscosity and elasticity of a RBC.
UR - http://www.scopus.com/inward/record.url?scp=85047021403&partnerID=8YFLogxK
U2 - 10.1109/MEMSYS.2018.8346502
DO - 10.1109/MEMSYS.2018.8346502
M3 - Conference contribution
AN - SCOPUS:85047021403
T3 - Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
SP - 137
EP - 140
BT - 2018 IEEE Micro Electro Mechanical Systems, MEMS 2018
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 31st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2018
Y2 - 21 January 2018 through 25 January 2018
ER -