Initial Gamma Knife radiosurgery for nonfunctioning pituitary adenomas: Clinical article

Cheng Chia Lee, Hideyuki Kano, Huai Che Yang, Zhiyuan Xu, Chun Po Yen, Wen Yuh Chung, David Hung Chi Pan, L. Dade Lunsford, Jason P. Sheehan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Object. Nonfunctioning pituitary adenomas (NFAs) are the most common type of pituitary adenoma and, when symptomatic, typically require surgical removal as an initial means of management. Gamma Knife radiosurgery (GKRS) is an alternative therapeutic strategy for patients whose comorbidities substantially increase the risks of resection. In this report, the authors evaluated the efficacy and safety of initial GKRS for NFAs. Methods. An international group of three academic Gamma Knife centers retrospectively reviewed outcome data in 569 patients with NFAs. Results. Forty-one patients (7.2%) underwent GKRS as primary management for their NFAs because of an advanced age, multiple comorbidities, or patient preference. The median age at the time of radiosurgery was 69 years. Thirty-seven percent of the patients had hypopituitarism before GKRS. Patients received a median tumor margin dose of 12 Gy (range 6.2-25.0 Gy) at a median isodose of 50%. The overall tumor control rate was 92.7%, and the actuarial tumor control rate was 94% and 85% at 5 and 10 years postradiosurgery, respectively. Three patients with tumor growth or symptom progression underwent resection at 3, 3, and 96 months after GKRS, respectively. New or worsened hypopituitarism developed in 10 patients (24%) at a median interval of 37 months after GKRS. One patient suffered new-onset cranial nerve palsy. No other radiosurgical complications were noted. Delayed hypopituitarism was observed more often in patients who had received a tumor margin dose > 18 Gy (p = 0.038) and a maximum dose > 36 Gy (p = 0.025). Conclusions. In this study, GKRS resulted in long-term control of NFAs in 85% of patients at 10 years. This experience suggests that GKRS provides long-term tumor control with an acceptable risk profile. This approach may be especially valuable in older patients, those with multiple comorbidities, and those who have endocrine-inactive tumors without visual compromise due to mass effect of the adenoma.

Original languageEnglish
Pages (from-to)647-654
Number of pages8
JournalJournal of Neurosurgery
Issue number3
StatePublished - Mar 2014


  • Gamma knife
  • Nonfunctioning
  • Oncology
  • Pituitary adenoma
  • Radiosurgery
  • Stereotactic radiosurgery
  • Transsphenoidal surgery


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