Inflammatory mediators of cerebrospinal fluid from patients with spinal cord injury

Ming Cheng Tsai; Chih Peng Wei; Dan Yang Lee; Yi Tzu Tseng; Ming Dar Tsai; Yung Luen Shih; Yi Hsuan Lee; Shwu Fen Chang; Sy Jye Leu

doi:10.1016/j.surneu.2007.09.033

Inflammatory mediators of cerebrospinal fluid from patients with spinal cord injury

Ming Cheng Tsai, Chih Peng Wei, Dan Yang Lee, Yi Tzu Tseng, Ming Dar Tsai, Yung Luen Shih, Yi Hsuan Lee, Shwu Fen Chang, Sy Jye Leu^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Background: The guidelines of MP treatment for acute SCI are still under debate. We examined the inflammatory mediators of CSF in patients with SCI and assessed the effect of MP treatment. Methods: We studied 7 patients with acute SCI at the cervical level and examined the mediators of CSF in patients by cytokine antibody array, ELISA and gelatin zymography. Results: We found that levels of IL-6, IL-8, monocyte chemoattractant protein-1, neutrophil-activating peptide 2, intracellular adhesion molecule-1, soluble Fas, tissue inhibitors of metalloproteinase 1, and matrix metalloproteinases-2 and -9 were upregulated in patients with complete SCI without MP treatment as compared to patients with MP treatments, incomplete SCI, or controls. Nerve growth factor was upregulated in patients with MP treatment. Conclusions: We suggest that a neuroinflammatory CSF profile after complete SCI could be suppressed with MP treatment via downregulating the expression of various cytokines.

Original language	English
Pages (from-to)	S19-S24
Journal	Surgical Neurology
Volume	70
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1016/j.surneu.2007.09.033
State	Published - Dec 2008

Keywords

Cytokine
Methylprednisolone
Spinal cord injury

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10.1016/j.surneu.2007.09.033

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@article{1a45ddbf98ef4462b3584800de193565,

title = "Inflammatory mediators of cerebrospinal fluid from patients with spinal cord injury",

abstract = "Background: The guidelines of MP treatment for acute SCI are still under debate. We examined the inflammatory mediators of CSF in patients with SCI and assessed the effect of MP treatment. Methods: We studied 7 patients with acute SCI at the cervical level and examined the mediators of CSF in patients by cytokine antibody array, ELISA and gelatin zymography. Results: We found that levels of IL-6, IL-8, monocyte chemoattractant protein-1, neutrophil-activating peptide 2, intracellular adhesion molecule-1, soluble Fas, tissue inhibitors of metalloproteinase 1, and matrix metalloproteinases-2 and -9 were upregulated in patients with complete SCI without MP treatment as compared to patients with MP treatments, incomplete SCI, or controls. Nerve growth factor was upregulated in patients with MP treatment. Conclusions: We suggest that a neuroinflammatory CSF profile after complete SCI could be suppressed with MP treatment via downregulating the expression of various cytokines.",

keywords = "Cytokine, Methylprednisolone, Spinal cord injury",

author = "Tsai, {Ming Cheng} and Wei, {Chih Peng} and Lee, {Dan Yang} and Tseng, {Yi Tzu} and Tsai, {Ming Dar} and Shih, {Yung Luen} and Lee, {Yi Hsuan} and Chang, {Shwu Fen} and Leu, {Sy Jye}",

note = "Funding Information: This study was supported by grants (SKH-TMU-93-17) from the Shin Kong Wu Ho-Su Memorial Hospital and NSC 94-2314-8-038-007, Taipei, Taiwan, to Dr. SJ Leu. ",

year = "2008",

month = dec,

doi = "10.1016/j.surneu.2007.09.033",

language = "English",

volume = "70",

pages = "S19--S24",

journal = "Surgical Neurology",

issn = "0090-3019",

publisher = "Elsevier B.V.",

number = "SUPPL. 1",

}

TY - JOUR

T1 - Inflammatory mediators of cerebrospinal fluid from patients with spinal cord injury

AU - Tsai, Ming Cheng

AU - Wei, Chih Peng

AU - Lee, Dan Yang

AU - Tseng, Yi Tzu

AU - Tsai, Ming Dar

AU - Shih, Yung Luen

AU - Lee, Yi Hsuan

AU - Chang, Shwu Fen

AU - Leu, Sy Jye

N1 - Funding Information: This study was supported by grants (SKH-TMU-93-17) from the Shin Kong Wu Ho-Su Memorial Hospital and NSC 94-2314-8-038-007, Taipei, Taiwan, to Dr. SJ Leu.

PY - 2008/12

Y1 - 2008/12

N2 - Background: The guidelines of MP treatment for acute SCI are still under debate. We examined the inflammatory mediators of CSF in patients with SCI and assessed the effect of MP treatment. Methods: We studied 7 patients with acute SCI at the cervical level and examined the mediators of CSF in patients by cytokine antibody array, ELISA and gelatin zymography. Results: We found that levels of IL-6, IL-8, monocyte chemoattractant protein-1, neutrophil-activating peptide 2, intracellular adhesion molecule-1, soluble Fas, tissue inhibitors of metalloproteinase 1, and matrix metalloproteinases-2 and -9 were upregulated in patients with complete SCI without MP treatment as compared to patients with MP treatments, incomplete SCI, or controls. Nerve growth factor was upregulated in patients with MP treatment. Conclusions: We suggest that a neuroinflammatory CSF profile after complete SCI could be suppressed with MP treatment via downregulating the expression of various cytokines.

AB - Background: The guidelines of MP treatment for acute SCI are still under debate. We examined the inflammatory mediators of CSF in patients with SCI and assessed the effect of MP treatment. Methods: We studied 7 patients with acute SCI at the cervical level and examined the mediators of CSF in patients by cytokine antibody array, ELISA and gelatin zymography. Results: We found that levels of IL-6, IL-8, monocyte chemoattractant protein-1, neutrophil-activating peptide 2, intracellular adhesion molecule-1, soluble Fas, tissue inhibitors of metalloproteinase 1, and matrix metalloproteinases-2 and -9 were upregulated in patients with complete SCI without MP treatment as compared to patients with MP treatments, incomplete SCI, or controls. Nerve growth factor was upregulated in patients with MP treatment. Conclusions: We suggest that a neuroinflammatory CSF profile after complete SCI could be suppressed with MP treatment via downregulating the expression of various cytokines.

KW - Cytokine

KW - Methylprednisolone

KW - Spinal cord injury

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DO - 10.1016/j.surneu.2007.09.033

M3 - Article

C2 - 19061765

AN - SCOPUS:56849122702

SN - 0090-3019

VL - 70

SP - S19-S24

JO - Surgical Neurology

JF - Surgical Neurology

IS - SUPPL. 1

ER -

Inflammatory mediators of cerebrospinal fluid from patients with spinal cord injury

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Keywords

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