Increased risk of type 2 diabetes among the siblings of patients with schizophrenia

Mao Hsuan Huang, Mu Hong Chen, Kai Lin Huang, Ju Wei Hsu*, Ya Mei Bai, Chih Ming Cheng, Tung Ping Su, Cheng Ta Li, Shih Jen Tsai, Wei Chen Lin, Albert C. Yang, Tzeng Ji Chen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Background: Research suggests an association between metabolic disorders, such as type 2 diabetes mellitus (T2DM), and schizophrenia. However, the risk of metabolic disorders in the unaffected siblings of patients with schizophrenia remains unclear. Methods: Using the Taiwan National Health Insurance Research Database, 3135 unaffected siblings of schizophrenia probands and 12,540 age-/sex-matched control subjects were included and followed up to the end of 2011. Individuals who developed metabolic disorders during the follow-up period were identified. Results: The unaffected siblings of schizophrenia probands had a higher prevalence of T2DM (3.4% vs. 2.6%, p = 0.010) than the controls. Logistic regression analyses with the adjustment of demographic data revealed that the unaffected siblings of patients with schizophrenia were more likely to develop T2DM (odds ratio [OR]: 1.39, 95% confidence interval [CI]: 1.10-1.75) later in life compared with the control group. Moreover, only female siblings of schizophrenia probands had an increased risk of hypertension (OR: 1.47, 95% CI: 1.07-2.01) during the follow-up compared with the controls. Discussion: The unaffected siblings, especially sisters, of schizophrenia probands had a higher prevalence of T2DM and hypertension compared with the controls. Our study revealed a familial link between schizophrenia and T2DM in a large sample. Additional studies are required to investigate the shared pathophysiology of schizophrenia and T2DM.

Original languageEnglish
Pages (from-to)453-459
Number of pages7
JournalCNS Spectrums
Volume24
Issue number4
DOIs
StatePublished - 1 Aug 2019

Keywords

  • Epidemiology
  • metabolic disorders
  • schizophrenia
  • siblings
  • type 2 diabetes mellitus

Fingerprint

Dive into the research topics of 'Increased risk of type 2 diabetes among the siblings of patients with schizophrenia'. Together they form a unique fingerprint.

Cite this