Increased risk of pulmonary tuberculosis in patients with gastroesophageal reflux disease

W. C. Fan; S. M. Ou; J. Y. Feng; Y. W. Hu; C. M. Yeh; V. Y.F. Su; L. Y. Hu; S. H. Chien; W. J. Su; T. J. Chen; C. J. Liu

doi:10.5588/ijtld.15.0251

Increased risk of pulmonary tuberculosis in patients with gastroesophageal reflux disease

W. C. Fan, S. M. Ou, J. Y. Feng^*, Y. W. Hu, C. M. Yeh, V. Y.F. Su, L. Y. Hu, S. H. Chien, W. J. Su, T. J. Chen, C. J. Liu

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

BACKGROUND: Previous studies have suggested a close correlation between gastroesophageal reflux disease (GERD) and various respiratory disorders. However, the association between GERD and tuberculosis (TB) remains unexplored. METHODS: Using data retrieved from Taiwan's National Health Insurance Research Database from 2000 to 2009, this longitudinal nationwide cohort study included a total of 63 930 patients with GERD and controls matched by age, sex and comorbidities. Risk factors associated with the development of pulmonary TB (PTB) were investigated. RESULTS: Active PTB was documented in 65 (0.20%) patients with GERD and 41 (0.13%) matched cohorts within 1 year of GERD diagnosis. The incidence rate of PTB in the GERD group and the matched cohort was respectively 24.1 and 15.2 cases per 10000 personyears. In multivariate analysis, GERD was an independent risk factor for PTB (adjusted HR 1.63, 95%CI 1.10-2.40, P = 0.015). Among patients with GERD, independent predictors for PTB included older age, male sex, chronic obstructive pulmonary disease, asthma and exposure to proton pump inhibitors (PPIs). CONCLUSION: Patients with GERD have a significantly increased risk of PTB within 1 year of GERD diagnosis. Exposure to PPIs is an independent predictor for PTB among patients with GERD.

Original language	English
Pages (from-to)	265-270
Number of pages	6
Journal	International Journal of Tuberculosis and Lung Disease
Volume	20
Issue number	2
DOIs	https://doi.org/10.5588/ijtld.15.0251
State	Published - 1 Feb 2016

Keywords

GERD
Proton pump inhibitors
Risk factors
TB

UN SDGs

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10.5588/ijtld.15.0251

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title = "Increased risk of pulmonary tuberculosis in patients with gastroesophageal reflux disease",

abstract = "BACKGROUND: Previous studies have suggested a close correlation between gastroesophageal reflux disease (GERD) and various respiratory disorders. However, the association between GERD and tuberculosis (TB) remains unexplored. METHODS: Using data retrieved from Taiwan's National Health Insurance Research Database from 2000 to 2009, this longitudinal nationwide cohort study included a total of 63 930 patients with GERD and controls matched by age, sex and comorbidities. Risk factors associated with the development of pulmonary TB (PTB) were investigated. RESULTS: Active PTB was documented in 65 (0.20%) patients with GERD and 41 (0.13%) matched cohorts within 1 year of GERD diagnosis. The incidence rate of PTB in the GERD group and the matched cohort was respectively 24.1 and 15.2 cases per 10000 personyears. In multivariate analysis, GERD was an independent risk factor for PTB (adjusted HR 1.63, 95%CI 1.10-2.40, P = 0.015). Among patients with GERD, independent predictors for PTB included older age, male sex, chronic obstructive pulmonary disease, asthma and exposure to proton pump inhibitors (PPIs). CONCLUSION: Patients with GERD have a significantly increased risk of PTB within 1 year of GERD diagnosis. Exposure to PPIs is an independent predictor for PTB among patients with GERD.",

keywords = "GERD, Proton pump inhibitors, Risk factors, TB",

author = "Fan, {W. C.} and Ou, {S. M.} and Feng, {J. Y.} and Hu, {Y. W.} and Yeh, {C. M.} and Su, {V. Y.F.} and Hu, {L. Y.} and Chien, {S. H.} and Su, {W. J.} and Chen, {T. J.} and Liu, {C. J.}",

note = "Publisher Copyright: {\textcopyright} 2016 The Union.",

year = "2016",

month = feb,

day = "1",

doi = "10.5588/ijtld.15.0251",

language = "English",

volume = "20",

pages = "265--270",

journal = "International Journal of Tuberculosis and Lung Disease",

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publisher = "International Union Against Tuberculosis and Lung Disease ",

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TY - JOUR

T1 - Increased risk of pulmonary tuberculosis in patients with gastroesophageal reflux disease

AU - Fan, W. C.

AU - Ou, S. M.

AU - Feng, J. Y.

AU - Hu, Y. W.

AU - Yeh, C. M.

AU - Su, V. Y.F.

AU - Hu, L. Y.

AU - Chien, S. H.

AU - Su, W. J.

AU - Chen, T. J.

AU - Liu, C. J.

PY - 2016/2/1

Y1 - 2016/2/1

N2 - BACKGROUND: Previous studies have suggested a close correlation between gastroesophageal reflux disease (GERD) and various respiratory disorders. However, the association between GERD and tuberculosis (TB) remains unexplored. METHODS: Using data retrieved from Taiwan's National Health Insurance Research Database from 2000 to 2009, this longitudinal nationwide cohort study included a total of 63 930 patients with GERD and controls matched by age, sex and comorbidities. Risk factors associated with the development of pulmonary TB (PTB) were investigated. RESULTS: Active PTB was documented in 65 (0.20%) patients with GERD and 41 (0.13%) matched cohorts within 1 year of GERD diagnosis. The incidence rate of PTB in the GERD group and the matched cohort was respectively 24.1 and 15.2 cases per 10000 personyears. In multivariate analysis, GERD was an independent risk factor for PTB (adjusted HR 1.63, 95%CI 1.10-2.40, P = 0.015). Among patients with GERD, independent predictors for PTB included older age, male sex, chronic obstructive pulmonary disease, asthma and exposure to proton pump inhibitors (PPIs). CONCLUSION: Patients with GERD have a significantly increased risk of PTB within 1 year of GERD diagnosis. Exposure to PPIs is an independent predictor for PTB among patients with GERD.

AB - BACKGROUND: Previous studies have suggested a close correlation between gastroesophageal reflux disease (GERD) and various respiratory disorders. However, the association between GERD and tuberculosis (TB) remains unexplored. METHODS: Using data retrieved from Taiwan's National Health Insurance Research Database from 2000 to 2009, this longitudinal nationwide cohort study included a total of 63 930 patients with GERD and controls matched by age, sex and comorbidities. Risk factors associated with the development of pulmonary TB (PTB) were investigated. RESULTS: Active PTB was documented in 65 (0.20%) patients with GERD and 41 (0.13%) matched cohorts within 1 year of GERD diagnosis. The incidence rate of PTB in the GERD group and the matched cohort was respectively 24.1 and 15.2 cases per 10000 personyears. In multivariate analysis, GERD was an independent risk factor for PTB (adjusted HR 1.63, 95%CI 1.10-2.40, P = 0.015). Among patients with GERD, independent predictors for PTB included older age, male sex, chronic obstructive pulmonary disease, asthma and exposure to proton pump inhibitors (PPIs). CONCLUSION: Patients with GERD have a significantly increased risk of PTB within 1 year of GERD diagnosis. Exposure to PPIs is an independent predictor for PTB among patients with GERD.

KW - GERD

KW - Proton pump inhibitors

KW - Risk factors

KW - TB

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VL - 20

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EP - 270

JO - International Journal of Tuberculosis and Lung Disease

JF - International Journal of Tuberculosis and Lung Disease

IS - 2

ER -

Increased risk of pulmonary tuberculosis in patients with gastroesophageal reflux disease

Abstract

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