Incidence and risk of atrial fibrillation in sleep-disordered breathing without coexistent systemic disease – Nationwide longitudinal cohort study –

Tze Fan Chao, Kang Ling Wang, Yenn Jiang Lin, Shih Lin Chang, Li Wei Lo, Yu Feng Hu, Ta Chuan Tuan, Shih Ann Chen, Chia Jen Liu, Su Jung Chen, Tzeng-Ji Chen, Kang Ling Wang, Yenn Jiang Lin, Shih Lin Chang, Li Wei Lo, Yu Feng Hu, Ta Chuan Tuan, Chuen Wang Chiou, Shih Ann Chen, Tze Fan ChaoTa Chuan Tuan, Chuen Wang Chiou

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Background: Although the link between sleep-disordered breathing (SDB) and atrial fibrillation (AF) has been reported, a population-based longitudinal cohort study was lacking. The goal of the present study was to investigate the AF risk carried by SDB, using the National Health Insurance Research Database in Taiwan.

Methods and Results: From 2000 to 2001, a total of 579,521 patients who had no history of cardiac arrhythmias or significant comorbidities were identified. Among them, 4,082 subjects with the diagnosis of SDB were selected as the study group, and the remaining 575,439 subjects constituted the control group. The study endpoint was the occurrence of new-onset AF. During a follow-up of 9.2±2.0 years, there were 4,023 patients (0.7%) experiencing new-onset AF. The occurrence rate of AF was higher in patients with SDB compared to those without it (1.3% vs. 0.7%, P<0.001). The AF incidences were 1.38 and 0.76 per 1,000 person-years for patients with and without SDB, respectively. After anadjustment for age and sex, SDB was a significant risk factor of AF with a hazard ratio of 1.536. The AF risk increased with increasing clinical severity of SDB, represented by the requirement of continuous positive airway pressure use.

Conclusions: SDB itself, without the coexistence of other systemic diseases, was a risk factor of AF.

Original languageEnglish
Pages (from-to)2182-2187
Number of pages6
JournalCirculation Journal
Volume78
Issue number9
DOIs
StatePublished - 1 Sep 2014

Keywords

  • Atrial fibrillation
  • Incidence
  • Sleep-disordered breathing

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