In-vivo wireless bio-diagnosis system for long-term bioactivity monitoring network

Chun Kuang Chen, Wen Jong Wu, Shih An Yu, Jhen Gang Huang, Yun Han Lin, Yih Fan Chen, Ming Hui Jin, Chih Min Wen, Cheng Yan Kao, Shi Ming Lin, Shey Shi Lu, Chii Wann Lin, Jia Yush Yen, Fu Shan Jaw, Chi An Chen, Fang Jen Liao, Nan Fu Chiu, Chia Nan Chien, Chih Kung Lee*

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review


Attempts to develop a Wireless Health Advanced Mobile Bio-diagnostic System (abbreviated as WHAM-BioS) have arisen from the need to monitor the health status of patients under long-term care programs. The proposed WHAM-BioS as presented here was developed by integrating various technologies: nano/MEMS technology, biotechnology, network/communication technology, and information technology. The biochips proposed not only detect certain diseases but will also report any abnormal status readings on the patient to the medical personnel immediately through the network system. Since long-term home care is typically involved, the parameters monitored must be analyzed and traced continuously over a long period of time. To minimize the intrusion to the patients, a wireless sensor embedded within a wireless network is highly recommended. To facilitate the widest possible use of various biochips, a smart sensor node concept was implemented. More specifically, various technologies and components such as built-in micro power generators, energy storage devices, initialization processes, no-waste bio-detection methodologies, embedded controllers, wireless warning signal transmissions, and power/data management were merged and integrated to create this novel technology. The design methodologies and the implementation schemes are detailed. Potential expansions of this newly developed technology to other applications regimes will be presented as well.

Original languageEnglish
Pages (from-to)288-297
Number of pages10
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 2004
EventHealth Monitoring and Smart Nondestructive Evaluation of Structural and Biological Systems III - San Diego, CA, United States
Duration: 15 Mar 200417 Mar 2004


  • Biomechanics
  • C-reaction protein
  • Embedded system
  • Micro power system
  • Micro/nano bio-sampling probe array
  • Optomechatronics system


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