In vitro and in vivo experimental studies of PM 2.5 on disease progression

Ching Chang Cho, Wen Yeh Hsieh, Chin Hung Tsai, Cheng Yi Chen, Hui Fang Chang, Chih-Sheng Lin*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

121 Scopus citations


Air pollution is a very critical issue worldwide, particularly in developing countries. Particulate matter (PM) is a type of air pollution that comprises a heterogeneous mixture of different particle sizes and chemical compositions. There are various sources of fine PM (PM 2.5 ), and the components may also have different effects on people. The pathogenesis of PM 2.5 in several diseases remains to be clarified. There is a long history of epidemiological research on PM 2.5 in several diseases. Numerous studies show that PM 2.5 can induce a variety of chronic diseases, such as respiratory system damage, cardiovascular dysfunction, and diabetes mellitus. However, the epidemiological evidence associated with potential mechanisms in the progression of diseases need to be proved precisely through in vitro and in vivo investigations. Suggested mechanisms of PM 2.5 that lead to adverse effects and chronic diseases include increasing oxidative stress, inflammatory responses, and genotoxicity. The aim of this review is to provide a brief overview of in vitro and in vivo experimental studies of PM 2.5 in the progression of various diseases from the last decade. The summarized research results could provide clear information about the mechanisms and progression of PM 2.5 -induced disease.

Original languageEnglish
Article number1380
JournalInternational journal of environmental research and public health
Issue number7
StatePublished - 1 Jul 2018


  • Animal model
  • Disease progression
  • In vitro study
  • PM
  • Particulate matter (PM)


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