TY - GEN
T1 - Improving the evaluation of cell deformability by different channel width in a microfluidic device
AU - Tsai, Chia-Hung
AU - Kaneko, Makoto
AU - Arai, Fumihito
PY - 2014/3/9
Y1 - 2014/3/9
N2 - A method for evaluating red blood cell (RBC) deformability by different channel width in a microfluidic device is proposed. While conventional methods usually have only one test channel to deform RBCs for the evaluation, a design including three test channels with different width is utilized in this work. The proposed design have the advantage of generating a wider range of deformation to each RBC, thus the RBC deformability can be appropriately determined. Experiments on normal RBCs are conducted, and RBC motion through the channels is recorded and analyzed. The velocity drop, the velocity difference between a RBC and flowing fluid, is utilized as an index for the RBC response during deformation. According to the analysis, the relation between the velocity drop and amount of deformation of the RBCs is found nicely fitted with a modified contact model with R2 = 0.91, and the RBC deformability is successfully evaluated as in two deformability constants Cd and ζ.
AB - A method for evaluating red blood cell (RBC) deformability by different channel width in a microfluidic device is proposed. While conventional methods usually have only one test channel to deform RBCs for the evaluation, a design including three test channels with different width is utilized in this work. The proposed design have the advantage of generating a wider range of deformation to each RBC, thus the RBC deformability can be appropriately determined. Experiments on normal RBCs are conducted, and RBC motion through the channels is recorded and analyzed. The velocity drop, the velocity difference between a RBC and flowing fluid, is utilized as an index for the RBC response during deformation. According to the analysis, the relation between the velocity drop and amount of deformation of the RBCs is found nicely fitted with a modified contact model with R2 = 0.91, and the RBC deformability is successfully evaluated as in two deformability constants Cd and ζ.
KW - Automation at Micro-Nano Scales
KW - Automation in Life Sciences
KW - Red Blood Cell
UR - http://www.scopus.com/inward/record.url?scp=84949924907&partnerID=8YFLogxK
U2 - 10.1109/URAI.2014.7057380
DO - 10.1109/URAI.2014.7057380
M3 - Conference contribution
AN - SCOPUS:84949924907
T3 - 2014 11th International Conference on Ubiquitous Robots and Ambient Intelligence, URAI 2014
SP - 522
EP - 524
BT - 2014 11th International Conference on Ubiquitous Robots and Ambient Intelligence, URAI 2014
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2014 11th International Conference on Ubiquitous Robots and Ambient Intelligence, URAI 2014
Y2 - 12 November 2014 through 15 November 2014
ER -