Immunoglobulin M antibodies against hepatitis C virus antigens: significance and applications

Pei Jer Chen; Lih Hwa Hwang; Li Yen Chang; Jia Horng Kao; Ding Shinn Chen

doi:10.1007/BF02989209

Immunoglobulin M antibodies against hepatitis C virus antigens: significance and applications

Pei Jer Chen^*, Lih Hwa Hwang, Li Yen Chang, Jia Horng Kao, Ding Shinn Chen

^*Corresponding author for this work

Institute of Microbiology and Immunology

Research output: Contribution to journal › Article › peer-review

Abstract

The immunoglobulin M antibody against hepatitis C viral capsid (core) antigen has been found to be a possible marker for acute infection in posttransfusion hepatitis C. We extended this observation to a spoadic hepatitis C. In addition, a modified recombinant immunoblot assay (RIBA) that contained three HCV antigens (capsid, NS3 and NS5) in one strip was developed and used to study the antibody response among patients. This allowed a simultaneous comparison of either immunoglobulin M or G specific to individual HCV antigen and yielded more information. The assay was found useful in the diagnosis of acute hepatitis C in clinically uncertain cases.

Original language	English
Pages (from-to)	67-70
Number of pages	4
Journal	Gastroenterologia Japonica
Volume	28
Issue number	5 Supplement
DOIs	https://doi.org/10.1007/BF02989209
State	Published - May 1993

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10.1007/BF02989209

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title = "Immunoglobulin M antibodies against hepatitis C virus antigens: significance and applications",

abstract = "The immunoglobulin M antibody against hepatitis C viral capsid (core) antigen has been found to be a possible marker for acute infection in posttransfusion hepatitis C. We extended this observation to a spoadic hepatitis C. In addition, a modified recombinant immunoblot assay (RIBA) that contained three HCV antigens (capsid, NS3 and NS5) in one strip was developed and used to study the antibody response among patients. This allowed a simultaneous comparison of either immunoglobulin M or G specific to individual HCV antigen and yielded more information. The assay was found useful in the diagnosis of acute hepatitis C in clinically uncertain cases.",

author = "Chen, {Pei Jer} and Hwang, {Lih Hwa} and Chang, {Li Yen} and Kao, {Jia Horng} and Chen, {Ding Shinn}",

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T2 - significance and applications

AU - Chen, Pei Jer

AU - Hwang, Lih Hwa

AU - Chang, Li Yen

AU - Kao, Jia Horng

AU - Chen, Ding Shinn

PY - 1993/5

Y1 - 1993/5

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AB - The immunoglobulin M antibody against hepatitis C viral capsid (core) antigen has been found to be a possible marker for acute infection in posttransfusion hepatitis C. We extended this observation to a spoadic hepatitis C. In addition, a modified recombinant immunoblot assay (RIBA) that contained three HCV antigens (capsid, NS3 and NS5) in one strip was developed and used to study the antibody response among patients. This allowed a simultaneous comparison of either immunoglobulin M or G specific to individual HCV antigen and yielded more information. The assay was found useful in the diagnosis of acute hepatitis C in clinically uncertain cases.

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M3 - Article

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EP - 70

JO - Gastroenterologia Japonica

JF - Gastroenterologia Japonica

IS - 5 Supplement

ER -

Immunoglobulin M antibodies against hepatitis C virus antigens: significance and applications

Abstract

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