Imaging pulsatile retinal blood flow in human eye

Bin Rao; Lingfeng Yu; Huihua Kenny Chiang; Leandro C. Zacharias; Ronald M. Kurtz; Baruch D. Kuppermann; Zhongping Chen

doi:10.1117/1.2967986

Imaging pulsatile retinal blood flow in human eye

Bin Rao^*, Lingfeng Yu, Huihua Kenny Chiang, Leandro C. Zacharias, Ronald M. Kurtz, Baruch D. Kuppermann, Zhongping Chen

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

A functional Fourier domain optical coherence tomography instrument offering spectral Doppler imaging of in vivo pulsatile human retinal blood flow was constructed. An improved phase-resolved algorithm was developed to correct bulk motion artifacts. Spectral Doppler imaging provides complementary temporal flow information to the spatially distributed flow information of the color Doppler image by providing direct visualization of the Doppler spectrum of the flow whose pattern can be further quantified with various velocity envelope curves and their corresponding flow indices. The coefficient of repeatability on resistance index measurement was assessed by analyzing 14 measurements on two vessels within two normal subjects.

Original language	English
Article number	040505
Journal	Journal of Biomedical Optics
Volume	13
Issue number	4
DOIs	https://doi.org/10.1117/1.2967986
State	Published - 2008

Keywords

doppler
interferometry
tomography

Access to Document

10.1117/1.2967986

Cite this

@article{986ecb5aea5a47e58a04f62d47f775b1,

title = "Imaging pulsatile retinal blood flow in human eye",

abstract = "A functional Fourier domain optical coherence tomography instrument offering spectral Doppler imaging of in vivo pulsatile human retinal blood flow was constructed. An improved phase-resolved algorithm was developed to correct bulk motion artifacts. Spectral Doppler imaging provides complementary temporal flow information to the spatially distributed flow information of the color Doppler image by providing direct visualization of the Doppler spectrum of the flow whose pattern can be further quantified with various velocity envelope curves and their corresponding flow indices. The coefficient of repeatability on resistance index measurement was assessed by analyzing 14 measurements on two vessels within two normal subjects.",

keywords = "doppler, interferometry, tomography",

author = "Bin Rao and Lingfeng Yu and Chiang, {Huihua Kenny} and Zacharias, {Leandro C.} and Kurtz, {Ronald M.} and Kuppermann, {Baruch D.} and Zhongping Chen",

note = "Funding Information: This work is supported by the National Institutes of Health (Grant No. EB-00293, No. NCI-91717, No. RR-01192), and the Air Force Office of Science Research (Grant No. FA9550-04-1-0101). Institutional support from the Beckman Laser Institute and Medical Clinic is also gratefully acknowledged.",

year = "2008",

doi = "10.1117/1.2967986",

language = "English",

volume = "13",

journal = "Journal of Biomedical Optics",

issn = "1083-3668",

publisher = "SPIE",

number = "4",

}

TY - JOUR

T1 - Imaging pulsatile retinal blood flow in human eye

AU - Rao, Bin

AU - Yu, Lingfeng

AU - Chiang, Huihua Kenny

AU - Zacharias, Leandro C.

AU - Kurtz, Ronald M.

AU - Kuppermann, Baruch D.

AU - Chen, Zhongping

N1 - Funding Information: This work is supported by the National Institutes of Health (Grant No. EB-00293, No. NCI-91717, No. RR-01192), and the Air Force Office of Science Research (Grant No. FA9550-04-1-0101). Institutional support from the Beckman Laser Institute and Medical Clinic is also gratefully acknowledged.

PY - 2008

Y1 - 2008

N2 - A functional Fourier domain optical coherence tomography instrument offering spectral Doppler imaging of in vivo pulsatile human retinal blood flow was constructed. An improved phase-resolved algorithm was developed to correct bulk motion artifacts. Spectral Doppler imaging provides complementary temporal flow information to the spatially distributed flow information of the color Doppler image by providing direct visualization of the Doppler spectrum of the flow whose pattern can be further quantified with various velocity envelope curves and their corresponding flow indices. The coefficient of repeatability on resistance index measurement was assessed by analyzing 14 measurements on two vessels within two normal subjects.

AB - A functional Fourier domain optical coherence tomography instrument offering spectral Doppler imaging of in vivo pulsatile human retinal blood flow was constructed. An improved phase-resolved algorithm was developed to correct bulk motion artifacts. Spectral Doppler imaging provides complementary temporal flow information to the spatially distributed flow information of the color Doppler image by providing direct visualization of the Doppler spectrum of the flow whose pattern can be further quantified with various velocity envelope curves and their corresponding flow indices. The coefficient of repeatability on resistance index measurement was assessed by analyzing 14 measurements on two vessels within two normal subjects.

KW - doppler

KW - interferometry

KW - tomography

UR - http://www.scopus.com/inward/record.url?scp=58149374694&partnerID=8YFLogxK

U2 - 10.1117/1.2967986

DO - 10.1117/1.2967986

M3 - Article

C2 - 19021308

AN - SCOPUS:58149374694

SN - 1083-3668

VL - 13

JO - Journal of Biomedical Optics

JF - Journal of Biomedical Optics

IS - 4

M1 - 040505

ER -

Imaging pulsatile retinal blood flow in human eye

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this