IL-15 does not affect IEL development in the thymus but regulates homeostasis of putative precursors and mature CD8αα+ IELs in the intestine

Yein Gei Lai, Mau Sheng Hou, Yaw Wen Hsu, Chin Ling Chang, Yae Huei Liou, Ming Han Tsai, Fan Lee, Nan Shih Liao*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

Mice devoid of the IL-15 system lose over 90% of CD8αα + TCRαβ and TCRγδ intestinal intraepithelial lymphocytes (iIELs). Previous work revealed that IL-15Rα and IL-15 expressed by parenchymal cells, but not by bone marrow-derived cells, are required for normal CD8αα+ iIEL homeostasis. However, it remains unclear when and how the IL-15 system affects CD8αα + iIELs through their development. This study found that IL-15Rα is dispensable for the thymic stage of CD8αα + TCRαβ and TCRγδ iIEL development but is required for the maintenance and/or differentiation of the putative lineage marker negative precursors in the intestinal epithelium, especially for the most mature CD8 single positive subset. Moreover, the IL-15 system directly supports the survival of mature CD8αα+ iIEL in vivo. Taken together, this study suggests that regulation of CD8αα+ iIEL homeostasis by the IL-15 system does not occur in the thymus but involves mature cells and putative precursors in the intestine.

Original languageEnglish
Pages (from-to)3757-3765
Number of pages9
JournalJournal of Immunology
Volume180
Issue number6
DOIs
StatePublished - 15 Mar 2008

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