IgA deficiency with membranous glomerulonephritis: a case report and review.

Jeng Bin Huang*, Wu Chang Yang, Ching Chung Hu, An Han Yang, Chih Ching Lin

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Selective immunoglobulin A (IgA) deficiency may result in a predisposition to recurrent sinopulmonary infection and allergic diseases. IgA deficiency may also play a role in the development of autoimmune disorders. Selective IgA deficiency associated with glomerulonephritis was rare, while the clinical presentation in IgA deficiency-associated glomerulonephritis was variable. We report an 83 year-old male with selective IgA deficiency associated with membranous glomerulonephritis. He presented with nephrotic syndrome. Percutaneous renal needle biopsy showed diffuse global thickening and rigidity of glomerular capillary walls, mildly diffuse segmental expansion of mesangial matrix, focal and cortical scar with segmental obsolescence of glomeruli. Heavy IgG and moderate C3 deposits were found on immunofluorescence. We also review the previous cases of IgA deficiency with glomerulonephritis. Several clues were rendered to establish the association between IgA deficiency and membranous glomerulonephritis.

Original languageEnglish
Pages (from-to)154-158
Number of pages5
JournalJournal of Nephrology
Issue number1
StatePublished - Jan 2003


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