Identification of humoral antigenic determinants in the hepatitis C virus NS3 protein

Lih Hwa Hwang; Pei Ming Yang; Ming Yang Lai; Bor Luen Chiang; Jia Horng Kao; Jin Town Wang; Shiau Yuan Lee; Huei Min Chian; Wei Kuang Chi; Yi Ding Chu; Pei Jer Chen; Ding Shinn Chen

doi:10.1093/infdis/174.1.173

Identification of humoral antigenic determinants in the hepatitis C virus NS3 protein

Lih Hwa Hwang, Pei Ming Yang, Ming Yang Lai, Bor Luen Chiang, Jia Horng Kao, Jin Town Wang, Shiau Yuan Lee, Huei Min Chian, Wei Kuang Chi, Yi Ding Chu, Pei Jer Chen, Ding Shinn Chen^*

^*Corresponding author for this work

Institute of Microbiology and Immunology

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Immunoblot analysis on serum samples from 90 patients with chronic hepatitis C virus infection revealed four putative immunogenic regions within the NS3 protein of the virus: E (around aa 1250/1251), A (within aa 1250- 1334), A/B (around aa 1323 and 1334), and B/C (around aa 1407 and 1412). Among them, region E was most immunodominant, and region A was recognized much less frequently by patients with cirrhosis than by those with chronic hepatitis (10% vs. 46%, χ² = 12.05. P < .01). The results suggest that region A might be a potential prognostic marker to differentiate chronic hepatitis from cirrhosis.

Original language	English
Pages (from-to)	173-176
Number of pages	4
Journal	Journal of Infectious Diseases
Volume	174
Issue number	1
DOIs	https://doi.org/10.1093/infdis/174.1.173
State	Published - 1996

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title = "Identification of humoral antigenic determinants in the hepatitis C virus NS3 protein",

abstract = "Immunoblot analysis on serum samples from 90 patients with chronic hepatitis C virus infection revealed four putative immunogenic regions within the NS3 protein of the virus: E (around aa 1250/1251), A (within aa 1250- 1334), A/B (around aa 1323 and 1334), and B/C (around aa 1407 and 1412). Among them, region E was most immunodominant, and region A was recognized much less frequently by patients with cirrhosis than by those with chronic hepatitis (10% vs. 46%, χ2 = 12.05. P < .01). The results suggest that region A might be a potential prognostic marker to differentiate chronic hepatitis from cirrhosis.",

author = "Hwang, {Lih Hwa} and Yang, {Pei Ming} and Lai, {Ming Yang} and Chiang, {Bor Luen} and Kao, {Jia Horng} and Wang, {Jin Town} and Lee, {Shiau Yuan} and Chian, {Huei Min} and Chi, {Wei Kuang} and Chu, {Yi Ding} and Chen, {Pei Jer} and Chen, {Ding Shinn}",

year = "1996",

doi = "10.1093/infdis/174.1.173",

language = "English",

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T1 - Identification of humoral antigenic determinants in the hepatitis C virus NS3 protein

AU - Hwang, Lih Hwa

AU - Yang, Pei Ming

AU - Lai, Ming Yang

AU - Chiang, Bor Luen

AU - Kao, Jia Horng

AU - Wang, Jin Town

AU - Lee, Shiau Yuan

AU - Chian, Huei Min

AU - Chi, Wei Kuang

AU - Chu, Yi Ding

AU - Chen, Pei Jer

AU - Chen, Ding Shinn

PY - 1996

Y1 - 1996

N2 - Immunoblot analysis on serum samples from 90 patients with chronic hepatitis C virus infection revealed four putative immunogenic regions within the NS3 protein of the virus: E (around aa 1250/1251), A (within aa 1250- 1334), A/B (around aa 1323 and 1334), and B/C (around aa 1407 and 1412). Among them, region E was most immunodominant, and region A was recognized much less frequently by patients with cirrhosis than by those with chronic hepatitis (10% vs. 46%, χ2 = 12.05. P < .01). The results suggest that region A might be a potential prognostic marker to differentiate chronic hepatitis from cirrhosis.

AB - Immunoblot analysis on serum samples from 90 patients with chronic hepatitis C virus infection revealed four putative immunogenic regions within the NS3 protein of the virus: E (around aa 1250/1251), A (within aa 1250- 1334), A/B (around aa 1323 and 1334), and B/C (around aa 1407 and 1412). Among them, region E was most immunodominant, and region A was recognized much less frequently by patients with cirrhosis than by those with chronic hepatitis (10% vs. 46%, χ2 = 12.05. P < .01). The results suggest that region A might be a potential prognostic marker to differentiate chronic hepatitis from cirrhosis.

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DO - 10.1093/infdis/174.1.173

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JF - Journal of Infectious Diseases

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Identification of humoral antigenic determinants in the hepatitis C virus NS3 protein

Abstract

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