Hypoxia- and glutathione-responsive polymer nanoparticles for treating normoxic and hypoxic cancer cells

Yu Han Wen, Kuo Wei Chen, Yu Ting Cheng, Lu Yi Yu, Yun Wei Lee, Chun Liang Lo*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Malignant tumors display several metabolic characteristics that differ from those of normal tissues. Although these characteristics contribute to aggressive tumor progression, they also offer potential strategies for targeting and treating cancer cells. In this study, we prepared crosslinked polymer nanoparticles (CLPNPs) to encapsulate two hydrophobic drugs, chrysin and ceramide, which are responsive to both hypoxia and glutathione (GSH). The morphology of the CLPNPs was spherical with a particle diameter of 160 nm and a monodisperse distribution. The CLPNPs exhibited hypoxia- and GSH-dependent size changes and drug release, selectively inducing cell death in H1299 cancer cells but not in L929 normal cells. The CLPNPs showed higher cytotoxicity toward H1299 cancer cells under hypoxic conditions than normoxic conditions because of hypoxia-triggered drug release. These results demonstrate that CLPNPs are suitable drug carriers for treating both normoxic and hypoxic cancer cells.

Original languageEnglish
Article number105053
JournalJournal of Drug Delivery Science and Technology
Volume89
DOIs
StatePublished - Nov 2023

Keywords

  • Cancer cells
  • Ceramide
  • Chrysin
  • Glutathione
  • Hypoxia
  • Nanoparticles

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