Hyperthermia induced by near-infrared laser-irradiated CsWO3 nanoparticles disintegrates preformed lysozyme amyloid fibrils

Po Sheng Hu*, Natalia Tomasovicova, Hsiu Jen Chou, Meng Chang Li, Marek Vojtko, Katarina Zakutanska, Jozefina Majorosova, Shean Jen Chen, Peter Kopcansky

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


This research study attempts to prove the concept of the applicability of hyperthermia to treating the lysozyme amyloid fibrils (LAF)’s self-assembled fibrillary aggregates by a feedback-modulated temperature controller ranging from 26 °C to 80 °C, and separately, by near-infrared (NIR) laser-irradiated cesium tungstate (CsWO3) nanoparticle (NPs). The dependence of the final morphology of the amyloidal assembly on external heating and the photothermal effect of the NPs on treating the fibrillary assembly were investigated and analyzed. Experimentally, atomic force microscopy (AFM), optical stereoscopy, and scanning electron microscopy (SEM) were used primarily to ensure mutual interaction between LAF and NPs, optically elucidate the surface contour and final fibrillary assembly upon the influence of thermal treatment, and further reveal fine-details of the optical samples. Finally, conclusive remarks are drawn that the fibrillary structures doped with the NPs exhibit an increasing degree of unique orthogonality. As the temperature rises, utter deformation of the dendritic structures of fibrillary assemblies at 70 °C was found, and NIR laser-irradiated CsWO3 NPs have been demonstrated to be useful in topically destructing pre-assembled LAFs, which may be conducive to the future development of neurodegenerative therapeutic techniques.

Original languageEnglish
Article number442
Pages (from-to)1-12
Number of pages12
Issue number3
StatePublished - Mar 2020


  • Cesium tungsten oxide nanoparticles
  • Hyperthermia
  • Lysozyme amyloid fibrils
  • Neurodegenerative diseases
  • Self-assembled nanocomposite


Dive into the research topics of 'Hyperthermia induced by near-infrared laser-irradiated CsWO3 nanoparticles disintegrates preformed lysozyme amyloid fibrils'. Together they form a unique fingerprint.

Cite this