Hyperlipidemia and statins affect neurological outcome in lumbar spine injury

Wu Fu Chung, Shih Wei Liu, Peng Yuan Chang, Feng Shu Lin, Li Fu Chen, Jau Ching Wu, Yu Chun Chen*, Laura Liu, Wen Cheng Huang, Henrich Cheng, Su Shun Lo

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The disabling pathophysiologic effects of lipid and neuroprotective effects of statins have recently been demonstrated for acute spinal cord injuries in animal models. This large scale population-based study aimed to investigate the effect hyperlipidemia and the use of statins in patients with lumbar spine injury. The National Health Insurance Research Database of Taiwan was used to identify patients with lumbar spine injury. A total of 2844 patients were grouped into three: no hyperlipidemia, hyperlipidemia using low-dose of statins (≤90 of the defined daily dosage (DDD)), and severe hyperlipidemia using high-dose of statins (>90 DDD). A Cox multiple regression model was used to compare the incidence rates of disability among the three groups. The results showed that patients with hyperlipidemia appeared a higher risk of permanent disability (adjusted HR = 1.38, p = 0.28). In subgroup analysis, patients with severe hyperlipidemia had a higher risk of disability (adjusted HR = 3.1, p < 0.004), whereas hyperlipidemia using low-dose statins had a similar risk of permanently disability (adjusted HR = 0.83, p = 0.661). Hyperlipidemia adversely affected the neurological outcomes of lumbar spinal injury. Statins may have the potential to reverse this higher risk of disability. However, this beneficiary effect of statins only existed in patients using a lower dose (≤90 DDD).

Original languageEnglish
Pages (from-to)402-413
Number of pages12
JournalInternational journal of environmental research and public health
Issue number1
StatePublished - 5 Jan 2015


  • Hyperlipidemia
  • Lumbar spine injury
  • National health insurance
  • Statins


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