Hybrid actuation for long-Term cell manipulation in a microfluidic channel

Koji Mizoue, Naoki Yagyu, Chia-Hung Tsai*, Makoto Kaneko

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

7 Scopus citations

Abstract

This paper proposes a hybrid actuation for long-Term cell manipulation in a microfluidic channel. While a conventional actuation can manipulate a cell, it usually cannot last for a very long time (i.e. less than 10 minutes) due to unavoidable pressure leak or drifts. The hybrid actuation is composed of two actuations where one is a gravity-based pressure system for macro-scale pressure balancing and the other is a piezo-Actuator-based pressure system for achieving high-response cell manipulation. By combining the two actuators together in the system, we demonstrate a successful cell manipulation in a microchannel for a much longer time. Based on the experimental results, the manipulation system is expected to continue performing a stable manipulation for hours. The working principle and experimental results are presented. The responses of coupled flow resistances are discussed based on experimental results.

Original languageEnglish
Title of host publication2017 IEEE International Conference on Advanced Intelligent Mechatronics, AIM 2017
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1089-1094
Number of pages6
ISBN (Electronic)9781509059980
DOIs
StatePublished - 21 Aug 2017
Event2017 IEEE International Conference on Advanced Intelligent Mechatronics, AIM 2017 - Munich, Germany
Duration: 3 Jul 20177 Jul 2017

Publication series

NameIEEE/ASME International Conference on Advanced Intelligent Mechatronics, AIM

Conference

Conference2017 IEEE International Conference on Advanced Intelligent Mechatronics, AIM 2017
Country/TerritoryGermany
CityMunich
Period3/07/177/07/17

Keywords

  • Cell manipulation
  • Hybrid system
  • Microfluidics

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