Human foamy virus bel1 sequence in patients with autoimmune rheumatic diseases

Kuang Hui Sun; Hsiao Yi Lin; Lee Wen Chen; Hsiao Yun Tai; Mei Lin Lin; Chi Kuang Feng; Jung Sung Sung; Hsin Fu Liu; Wu Tse Liu

doi:10.1007/s10067-005-0146-5

Human foamy virus bel1 sequence in patients with autoimmune rheumatic diseases

Kuang Hui Sun^*, Hsiao Yi Lin, Lee Wen Chen, Hsiao Yun Tai, Mei Lin Lin, Chi Kuang Feng, Jung Sung Sung, Hsin Fu Liu, Wu Tse Liu

^*Corresponding author for this work

Department of Biotechnology and Laboratory Science in Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Since the association between human foamy virus (HFV) with rheumatic autoimmune diseases remains controversial, this study was designed to determine the relationship between HFV and systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), or progressive systemic sclerosis (PSS). The bel1 and Pol sequences of HFV were measured by reverse transcriptase-polymerase chain reaction (RT-PCR) in plasma and by PCR in peripheral blood mononuclear cells (PBMC) from patients with SLE, RA, and PSS. Antibodies against Bel1 and Pol were assessed by enzyme-linked immunosorbent assay. Active HFV infections were detected by a Bel1-responsive indicator cell line. The bel1 sequence was detected in the plasma (SLE 59, RA 32, and PSS 63%) and PBMC (SLE 54, RA 71, and PSS 57%). However, active HFV infection existed only in patients with the bel1 sequence in both plasma and PBMC. In SLE patients, antibodies against Bel1 (7.1%) and Pol (4.5%) were also detected. The results suggest a possible association between HFV infection and these autoimmune rheumatic diseases.

Original language	English
Pages (from-to)	694-699
Number of pages	6
Journal	Clinical Rheumatology
Volume	25
Issue number	5
DOIs	https://doi.org/10.1007/s10067-005-0146-5
State	Published - Sep 2006

Keywords

Human foamy virus
Progressive systemic sclerosis
Rheumatoid arthritis
Systemic lupus erythematosus

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10.1007/s10067-005-0146-5

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title = "Human foamy virus bel1 sequence in patients with autoimmune rheumatic diseases",

abstract = "Since the association between human foamy virus (HFV) with rheumatic autoimmune diseases remains controversial, this study was designed to determine the relationship between HFV and systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), or progressive systemic sclerosis (PSS). The bel1 and Pol sequences of HFV were measured by reverse transcriptase-polymerase chain reaction (RT-PCR) in plasma and by PCR in peripheral blood mononuclear cells (PBMC) from patients with SLE, RA, and PSS. Antibodies against Bel1 and Pol were assessed by enzyme-linked immunosorbent assay. Active HFV infections were detected by a Bel1-responsive indicator cell line. The bel1 sequence was detected in the plasma (SLE 59, RA 32, and PSS 63%) and PBMC (SLE 54, RA 71, and PSS 57%). However, active HFV infection existed only in patients with the bel1 sequence in both plasma and PBMC. In SLE patients, antibodies against Bel1 (7.1%) and Pol (4.5%) were also detected. The results suggest a possible association between HFV infection and these autoimmune rheumatic diseases.",

keywords = "Human foamy virus, Progressive systemic sclerosis, Rheumatoid arthritis, Systemic lupus erythematosus",

author = "Sun, {Kuang Hui} and Lin, {Hsiao Yi} and Chen, {Lee Wen} and Tai, {Hsiao Yun} and Lin, {Mei Lin} and Feng, {Chi Kuang} and Sung, {Jung Sung} and Liu, {Hsin Fu} and Liu, {Wu Tse}",

note = "Funding Information: Acknowledgements This study was supported in part by grants (NSC89-2314-B-010-045 and NSC91-2314-B-010-025) from the National Science Council, the Yen Tjing Ling Medical Research Foundation (CI-91-2-2), and the VTY Joint Research Program, Tsou's Foundation (VTY 91-P5-41), ROC.",

year = "2006",

month = sep,

doi = "10.1007/s10067-005-0146-5",

language = "English",

volume = "25",

pages = "694--699",

journal = "Clinical Rheumatology",

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AU - Sun, Kuang Hui

AU - Lin, Hsiao Yi

AU - Chen, Lee Wen

AU - Tai, Hsiao Yun

AU - Lin, Mei Lin

AU - Feng, Chi Kuang

AU - Sung, Jung Sung

AU - Liu, Hsin Fu

AU - Liu, Wu Tse

N1 - Funding Information: Acknowledgements This study was supported in part by grants (NSC89-2314-B-010-045 and NSC91-2314-B-010-025) from the National Science Council, the Yen Tjing Ling Medical Research Foundation (CI-91-2-2), and the VTY Joint Research Program, Tsou's Foundation (VTY 91-P5-41), ROC.

PY - 2006/9

Y1 - 2006/9

N2 - Since the association between human foamy virus (HFV) with rheumatic autoimmune diseases remains controversial, this study was designed to determine the relationship between HFV and systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), or progressive systemic sclerosis (PSS). The bel1 and Pol sequences of HFV were measured by reverse transcriptase-polymerase chain reaction (RT-PCR) in plasma and by PCR in peripheral blood mononuclear cells (PBMC) from patients with SLE, RA, and PSS. Antibodies against Bel1 and Pol were assessed by enzyme-linked immunosorbent assay. Active HFV infections were detected by a Bel1-responsive indicator cell line. The bel1 sequence was detected in the plasma (SLE 59, RA 32, and PSS 63%) and PBMC (SLE 54, RA 71, and PSS 57%). However, active HFV infection existed only in patients with the bel1 sequence in both plasma and PBMC. In SLE patients, antibodies against Bel1 (7.1%) and Pol (4.5%) were also detected. The results suggest a possible association between HFV infection and these autoimmune rheumatic diseases.

AB - Since the association between human foamy virus (HFV) with rheumatic autoimmune diseases remains controversial, this study was designed to determine the relationship between HFV and systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), or progressive systemic sclerosis (PSS). The bel1 and Pol sequences of HFV were measured by reverse transcriptase-polymerase chain reaction (RT-PCR) in plasma and by PCR in peripheral blood mononuclear cells (PBMC) from patients with SLE, RA, and PSS. Antibodies against Bel1 and Pol were assessed by enzyme-linked immunosorbent assay. Active HFV infections were detected by a Bel1-responsive indicator cell line. The bel1 sequence was detected in the plasma (SLE 59, RA 32, and PSS 63%) and PBMC (SLE 54, RA 71, and PSS 57%). However, active HFV infection existed only in patients with the bel1 sequence in both plasma and PBMC. In SLE patients, antibodies against Bel1 (7.1%) and Pol (4.5%) were also detected. The results suggest a possible association between HFV infection and these autoimmune rheumatic diseases.

KW - Human foamy virus

KW - Progressive systemic sclerosis

KW - Rheumatoid arthritis

KW - Systemic lupus erythematosus

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JO - Clinical Rheumatology

JF - Clinical Rheumatology

IS - 5

ER -

Human foamy virus bel1 sequence in patients with autoimmune rheumatic diseases

Abstract

Keywords

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