Huge adenomatous hyperplasia of the liver

Liang Kung Chen, Feng Chi Chang, Chiung Ru Lai, Jiing Chyuan Luo, Shih Tzu Tsai, Shinn Jang Hwang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Adenomatous hyperplasia (AH) of the liver is defined as a regenerative overgrowth with limited growth potential. Patients with AH of the liver usually have cirrhosis of the liver as well. Adenomatous hyperplasia is also described as a benign nodule more than 8 mm, which is the main differentiation between AH and regeneration nodules (which are less than 8 mm). Adenomatous hyperplasias more than 20 mm is extremely rare in the clinicopathologic studies. We present two cases of extraordinarily large AH (one was 100 mm and the other, 30 mm). Both patients were alcoholic, and one also had viral hepatitis B. By clinical, biochemical, and upper gastrointestinal endoscopic examinations, we diagnosed liver cirrhosis in both. Sizable nodules were discovered in their livers using imaging studies (including ultrasonography, computed tomography, magnetic resonance imaging, and positron emission tomography), and percutaneous liver biopsies of the nodules showed their cirrhotic background. However, neither of the patients developed hepatocellular carcinoma during the follow-up period.

Original languageEnglish
Pages (from-to)272-274
Number of pages3
JournalJournal of Clinical Gastroenterology
Issue number3
StatePublished - 2002


  • Adenomatous hyperplasia
  • Alcoholic liver disease
  • Liver cirrhosis
  • Macroregenerative nodule


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