Host-guest interaction of rotaxane assembly through selective detection of ferric ion: Insight into hemin sensing and switching with sodium ascorbate

Tarun Shukla; Atul Kumar Dwivedi; Reguram Arumugaperumal; Chien Min Lin; San-Yuan Chen; Hong-Cheu Lin

doi:10.1016/j.dyepig.2016.03.049

Host-guest interaction of rotaxane assembly through selective detection of ferric ion: Insight into hemin sensing and switching with sodium ascorbate

Tarun Shukla, Atul Kumar Dwivedi, Reguram Arumugaperumal, Chien Min Lin, San-Yuan Chen, Hong-Cheu Lin^*

^*Corresponding author for this work

Department of Materials Science and Engineering

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

A mechanically interlocked host rotaxane was synthesized by incorporation of tetraphenylethylene and phenanthroimidazole units in the axle to exhibit significant emission bands and demonstrate host-guest interactions via its topologically constrained cavity, and thus to induce a significant and selective fluorescence quenching of rotaxane towards ferric ion (Fe³⁺). The quenching efficiencies of rotaxane with both ferric ion (Fe³⁺) and bio-molecular Hemin (containing ferric ion) were investigated to compare the sensitivities of rotaxane for ferric ion and bio-molecular Hemin. The present study could probe host-guest interactions of rotaxane with ferric ion (Fe³⁺) and Hemin as well as monitoring the biological conversion of Hemin to Heme in presence of sodium ascorbate (as a reducing agent), where the reduced non-toxic Heme could be generated from the toxic form of Hemin.

Original language	English
Pages (from-to)	49-59
Number of pages	11
Journal	Dyes and Pigments
Volume	131
DOIs	https://doi.org/10.1016/j.dyepig.2016.03.049
State	Published - 1 Aug 2016

Keywords

Aggregation induced emission
Ferric ion
Host-guest interaction
Rotaxane
Tetraphenylethylene

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title = "Host-guest interaction of rotaxane assembly through selective detection of ferric ion: Insight into hemin sensing and switching with sodium ascorbate",

abstract = "A mechanically interlocked host rotaxane was synthesized by incorporation of tetraphenylethylene and phenanthroimidazole units in the axle to exhibit significant emission bands and demonstrate host-guest interactions via its topologically constrained cavity, and thus to induce a significant and selective fluorescence quenching of rotaxane towards ferric ion (Fe3+). The quenching efficiencies of rotaxane with both ferric ion (Fe3+) and bio-molecular Hemin (containing ferric ion) were investigated to compare the sensitivities of rotaxane for ferric ion and bio-molecular Hemin. The present study could probe host-guest interactions of rotaxane with ferric ion (Fe3+) and Hemin as well as monitoring the biological conversion of Hemin to Heme in presence of sodium ascorbate (as a reducing agent), where the reduced non-toxic Heme could be generated from the toxic form of Hemin.",

keywords = "Aggregation induced emission, Ferric ion, Host-guest interaction, Rotaxane, Tetraphenylethylene",

author = "Tarun Shukla and Dwivedi, {Atul Kumar} and Reguram Arumugaperumal and Lin, {Chien Min} and San-Yuan Chen and Hong-Cheu Lin",

year = "2016",

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doi = "10.1016/j.dyepig.2016.03.049",

language = "English",

volume = "131",

pages = "49--59",

journal = "Dyes and Pigments",

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TY - JOUR

T1 - Host-guest interaction of rotaxane assembly through selective detection of ferric ion

T2 - Insight into hemin sensing and switching with sodium ascorbate

AU - Shukla, Tarun

AU - Dwivedi, Atul Kumar

AU - Arumugaperumal, Reguram

AU - Lin, Chien Min

AU - Chen, San-Yuan

AU - Lin, Hong-Cheu

PY - 2016/8/1

Y1 - 2016/8/1

N2 - A mechanically interlocked host rotaxane was synthesized by incorporation of tetraphenylethylene and phenanthroimidazole units in the axle to exhibit significant emission bands and demonstrate host-guest interactions via its topologically constrained cavity, and thus to induce a significant and selective fluorescence quenching of rotaxane towards ferric ion (Fe3+). The quenching efficiencies of rotaxane with both ferric ion (Fe3+) and bio-molecular Hemin (containing ferric ion) were investigated to compare the sensitivities of rotaxane for ferric ion and bio-molecular Hemin. The present study could probe host-guest interactions of rotaxane with ferric ion (Fe3+) and Hemin as well as monitoring the biological conversion of Hemin to Heme in presence of sodium ascorbate (as a reducing agent), where the reduced non-toxic Heme could be generated from the toxic form of Hemin.

AB - A mechanically interlocked host rotaxane was synthesized by incorporation of tetraphenylethylene and phenanthroimidazole units in the axle to exhibit significant emission bands and demonstrate host-guest interactions via its topologically constrained cavity, and thus to induce a significant and selective fluorescence quenching of rotaxane towards ferric ion (Fe3+). The quenching efficiencies of rotaxane with both ferric ion (Fe3+) and bio-molecular Hemin (containing ferric ion) were investigated to compare the sensitivities of rotaxane for ferric ion and bio-molecular Hemin. The present study could probe host-guest interactions of rotaxane with ferric ion (Fe3+) and Hemin as well as monitoring the biological conversion of Hemin to Heme in presence of sodium ascorbate (as a reducing agent), where the reduced non-toxic Heme could be generated from the toxic form of Hemin.

KW - Aggregation induced emission

KW - Ferric ion

KW - Host-guest interaction

KW - Rotaxane

KW - Tetraphenylethylene

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U2 - 10.1016/j.dyepig.2016.03.049

DO - 10.1016/j.dyepig.2016.03.049

M3 - Article

AN - SCOPUS:84964499607

SN - 0143-7208

VL - 131

SP - 49

EP - 59

JO - Dyes and Pigments

JF - Dyes and Pigments

ER -

Host-guest interaction of rotaxane assembly through selective detection of ferric ion: Insight into hemin sensing and switching with sodium ascorbate

Abstract

Keywords

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