Highly Sensitive and Selective Detection of Melatonin in Biofluids by Antipyrine Based Fluorophore

Sathya Vijayakumar; Srinivasadesikan Venkatesan; Ming Chang Lin; Padmini Vediappen

doi:10.1007/s10895-022-03052-8

Highly Sensitive and Selective Detection of Melatonin in Biofluids by Antipyrine Based Fluorophore

Sathya Vijayakumar, Srinivasadesikan Venkatesan, Ming Chang Lin, Padmini Vediappen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

A simple fluorescent based organic fluorophore was synthesized and it shows significant fluorescent intensity with melatonin (MLN). Hence, it was applicable to the detection of MLN by colorimetric and fluorimetric techniques at neutral pH. Under optimized experimental condition, the synthesized organic fluorophore detects MLN selectively in the presence of other interfering biomolecules through ICT mechanism. The melatonin sensing mechanism is supported by DFT and ¹H-NMR titration. Based on the findings, this method can be applied to design a simple clinical diagnostic tool for MLN. Graphical Abstract: [Figure not available: see fulltext.].

Original language	English
Pages (from-to)	383-392
Number of pages	10
Journal	Journal of Fluorescence
Volume	33
Issue number	1
DOIs	https://doi.org/10.1007/s10895-022-03052-8
State	Published - Jan 2023

Keywords

Antipyrine derivative
Circadian Rhythm
Fluorescence
Melatonin
Sensor

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title = "Highly Sensitive and Selective Detection of Melatonin in Biofluids by Antipyrine Based Fluorophore",

abstract = "A simple fluorescent based organic fluorophore was synthesized and it shows significant fluorescent intensity with melatonin (MLN). Hence, it was applicable to the detection of MLN by colorimetric and fluorimetric techniques at neutral pH. Under optimized experimental condition, the synthesized organic fluorophore detects MLN selectively in the presence of other interfering biomolecules through ICT mechanism. The melatonin sensing mechanism is supported by DFT and 1H-NMR titration. Based on the findings, this method can be applied to design a simple clinical diagnostic tool for MLN. Graphical Abstract: [Figure not available: see fulltext.].",

keywords = "Antipyrine derivative, Circadian Rhythm, Fluorescence, Melatonin, Sensor",

author = "Sathya Vijayakumar and Srinivasadesikan Venkatesan and Lin, {Ming Chang} and Padmini Vediappen",

note = "Publisher Copyright: {\textcopyright} 2022, This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.",

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T1 - Highly Sensitive and Selective Detection of Melatonin in Biofluids by Antipyrine Based Fluorophore

AU - Vijayakumar, Sathya

AU - Venkatesan, Srinivasadesikan

AU - Lin, Ming Chang

AU - Vediappen, Padmini

PY - 2023/1

Y1 - 2023/1

N2 - A simple fluorescent based organic fluorophore was synthesized and it shows significant fluorescent intensity with melatonin (MLN). Hence, it was applicable to the detection of MLN by colorimetric and fluorimetric techniques at neutral pH. Under optimized experimental condition, the synthesized organic fluorophore detects MLN selectively in the presence of other interfering biomolecules through ICT mechanism. The melatonin sensing mechanism is supported by DFT and 1H-NMR titration. Based on the findings, this method can be applied to design a simple clinical diagnostic tool for MLN. Graphical Abstract: [Figure not available: see fulltext.].

AB - A simple fluorescent based organic fluorophore was synthesized and it shows significant fluorescent intensity with melatonin (MLN). Hence, it was applicable to the detection of MLN by colorimetric and fluorimetric techniques at neutral pH. Under optimized experimental condition, the synthesized organic fluorophore detects MLN selectively in the presence of other interfering biomolecules through ICT mechanism. The melatonin sensing mechanism is supported by DFT and 1H-NMR titration. Based on the findings, this method can be applied to design a simple clinical diagnostic tool for MLN. Graphical Abstract: [Figure not available: see fulltext.].

KW - Antipyrine derivative

KW - Circadian Rhythm

KW - Fluorescence

KW - Melatonin

KW - Sensor

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SN - 1053-0509

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SP - 383

EP - 392

JO - Journal of Fluorescence

JF - Journal of Fluorescence

IS - 1

ER -

Highly Sensitive and Selective Detection of Melatonin in Biofluids by Antipyrine Based Fluorophore

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