Highly conserved influenza A virus epitope sequences as candidates of H3N2 flu vaccine targets

Ko Wen Wu, Chih Yi Chien, Shiao Wen Li, Chwan Chuen King, Chuan Hsiung Chang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

This study focused on identifying the conserved epitopes in a single subtype A (H3N2)-as candidates for vaccine targets. We identified a total of 32 conserved epitopes in four viral proteins [22 HA, 4PB1, 3 NA, 3 NP]. Evaluation of conserved epitopes in coverage during 1968-2010 revealed that (1) 12 HA conserved epitopes were highly present in the circulating viruses; (2) the remaining 10 HA conserved epitopes appeared with lower percentage but a significantly increasing trend after 1989 [p < 0.001]; and (3) the conserved epitopes in NA, NP and PB1 are also highly frequent in wild-type viruses. These conserved epitopes also covered an extremely high percentage of the 16 vaccine strains during the 42. year period. The identification of highly conserved epitopes using our approach can also be applied to develop broad-spectrum vaccines.

Original languageEnglish
Pages (from-to)102-109
Number of pages8
JournalGenomics
Volume100
Issue number2
DOIs
StatePublished - Aug 2012

Keywords

  • Bioinformatics
  • Broad-spectrum vaccine
  • Epitope
  • Influenza virus

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