Highlight of severe acute respiratory syndrome coronavirus-2 vaccine development against COVID-19 pandemic

Cheng Hsuan Liu; Hsuan Yang Huang; Yung Fang Tu; Wei Yi Lai; Chia Lin Wang; Jun Ren Sun; Yueh Chien; Tzu Wei Lin; Yi Ying Lin; Chian Shiu Chien; Chih Heng Huang; Yuh Min Chen; Pin I. Huang; Fu Der Wang; Yi Ping Yang

doi:10.1097/JCMA.0000000000000461

Highlight of severe acute respiratory syndrome coronavirus-2 vaccine development against COVID-19 pandemic

Cheng Hsuan Liu, Hsuan Yang Huang, Yung Fang Tu, Wei Yi Lai, Chia Lin Wang, Jun Ren Sun, Yueh Chien, Tzu Wei Lin, Yi Ying Lin, Chian Shiu Chien, Chih Heng Huang, Yuh Min Chen, Pin I. Huang, Fu Der Wang, Yi Ping Yang^*

^*Corresponding author for this work

Department and Institute of Physiology

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

The pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has brought an unprecedented impact upon the global economy and public health. Although the SARS-CoV-2 virology has been gradually investigated, measures to combat this new threat in public health are still absent. To date, no certificated drug or vaccine has been developed for the treatment or prevention of coronavirus disease Extensive researches and international coordination has been conducted to rapidly develop novel vaccines against SARS-CoV-2 pandemic. Several major breakthroughs have been made through the identification of the genetic sequence and structural/non-structural proteins of SARS-CoV-2, which enabled the development of RNA-, DNA-based vaccines, subunit vaccines, and attenuated viral vaccines. In this review article, we present an overview of the recent advances of SARS-CoV-2 vaccines and the challenges that may be encountered in the development process, highlighting the advantages and disadvantages of these approaches that may help in effectively countering COVID-19.

Original language	English
Pages (from-to)	9-13
Number of pages	5
Journal	Journal of the Chinese Medical Association
Volume	84
Issue number	1
DOIs	https://doi.org/10.1097/JCMA.0000000000000461
State	Published - Jan 2021

Keywords

COVID-19
SARS-CoV-2
Vaccine development

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/JCMA.0000000000000461

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Liu, C. H., Huang, H. Y., Tu, Y. F., Lai, W. Y., Wang, C. L., Sun, J. R., Chien, Y., Lin, T. W., Lin, Y. Y., Chien, C. S., Huang, C. H., Chen, Y. M., Huang, P. I., Wang, F. D., & Yang, Y. P. (2021). Highlight of severe acute respiratory syndrome coronavirus-2 vaccine development against COVID-19 pandemic. Journal of the Chinese Medical Association, 84(1), 9-13. https://doi.org/10.1097/JCMA.0000000000000461

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title = "Highlight of severe acute respiratory syndrome coronavirus-2 vaccine development against COVID-19 pandemic",

abstract = "The pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has brought an unprecedented impact upon the global economy and public health. Although the SARS-CoV-2 virology has been gradually investigated, measures to combat this new threat in public health are still absent. To date, no certificated drug or vaccine has been developed for the treatment or prevention of coronavirus disease Extensive researches and international coordination has been conducted to rapidly develop novel vaccines against SARS-CoV-2 pandemic. Several major breakthroughs have been made through the identification of the genetic sequence and structural/non-structural proteins of SARS-CoV-2, which enabled the development of RNA-, DNA-based vaccines, subunit vaccines, and attenuated viral vaccines. In this review article, we present an overview of the recent advances of SARS-CoV-2 vaccines and the challenges that may be encountered in the development process, highlighting the advantages and disadvantages of these approaches that may help in effectively countering COVID-19.",

keywords = "COVID-19, SARS-CoV-2, Vaccine development",

author = "Liu, {Cheng Hsuan} and Huang, {Hsuan Yang} and Tu, {Yung Fang} and Lai, {Wei Yi} and Wang, {Chia Lin} and Sun, {Jun Ren} and Yueh Chien and Lin, {Tzu Wei} and Lin, {Yi Ying} and Chien, {Chian Shiu} and Huang, {Chih Heng} and Chen, {Yuh Min} and Huang, {Pin I.} and Wang, {Fu Der} and Yang, {Yi Ping}",

note = "Publisher Copyright: Copyright {\textcopyright} 2020, the Chinese Medical Association.",

year = "2021",

month = jan,

doi = "10.1097/JCMA.0000000000000461",

language = "English",

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Liu, CH, Huang, HY, Tu, YF, Lai, WY, Wang, CL, Sun, JR, Chien, Y, Lin, TW, Lin, YY, Chien, CS, Huang, CH, Chen, YM, Huang, PI, Wang, FD & Yang, YP 2021, 'Highlight of severe acute respiratory syndrome coronavirus-2 vaccine development against COVID-19 pandemic', Journal of the Chinese Medical Association, vol. 84, no. 1, pp. 9-13. https://doi.org/10.1097/JCMA.0000000000000461

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AU - Liu, Cheng Hsuan

AU - Huang, Hsuan Yang

AU - Tu, Yung Fang

AU - Lai, Wei Yi

AU - Wang, Chia Lin

AU - Sun, Jun Ren

AU - Chien, Yueh

AU - Lin, Tzu Wei

AU - Lin, Yi Ying

AU - Chien, Chian Shiu

AU - Huang, Chih Heng

AU - Chen, Yuh Min

AU - Huang, Pin I.

AU - Wang, Fu Der

AU - Yang, Yi Ping

PY - 2021/1

Y1 - 2021/1

N2 - The pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has brought an unprecedented impact upon the global economy and public health. Although the SARS-CoV-2 virology has been gradually investigated, measures to combat this new threat in public health are still absent. To date, no certificated drug or vaccine has been developed for the treatment or prevention of coronavirus disease Extensive researches and international coordination has been conducted to rapidly develop novel vaccines against SARS-CoV-2 pandemic. Several major breakthroughs have been made through the identification of the genetic sequence and structural/non-structural proteins of SARS-CoV-2, which enabled the development of RNA-, DNA-based vaccines, subunit vaccines, and attenuated viral vaccines. In this review article, we present an overview of the recent advances of SARS-CoV-2 vaccines and the challenges that may be encountered in the development process, highlighting the advantages and disadvantages of these approaches that may help in effectively countering COVID-19.

AB - The pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has brought an unprecedented impact upon the global economy and public health. Although the SARS-CoV-2 virology has been gradually investigated, measures to combat this new threat in public health are still absent. To date, no certificated drug or vaccine has been developed for the treatment or prevention of coronavirus disease Extensive researches and international coordination has been conducted to rapidly develop novel vaccines against SARS-CoV-2 pandemic. Several major breakthroughs have been made through the identification of the genetic sequence and structural/non-structural proteins of SARS-CoV-2, which enabled the development of RNA-, DNA-based vaccines, subunit vaccines, and attenuated viral vaccines. In this review article, we present an overview of the recent advances of SARS-CoV-2 vaccines and the challenges that may be encountered in the development process, highlighting the advantages and disadvantages of these approaches that may help in effectively countering COVID-19.

KW - COVID-19

KW - SARS-CoV-2

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JO - Journal of the Chinese Medical Association

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ER -

Highlight of severe acute respiratory syndrome coronavirus-2 vaccine development against COVID-19 pandemic

Abstract

Keywords

UN SDGs

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