High sensitivity CIP2A detection for oral cancer using a rapid transistor-based biosensor module

Minghan Xian, Jenna L. Stephany, Chan Wen Chiu, Chao Ching Chiang, Fan Ren, Cheng Tse Tsai, Siang Sin Shan, Yu Te Liao, Josephine F. Esquivel-Upshaw, Stephen J. Pearton

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Oral squamous cell carcinoma (OSCC) is one of the most common lip and oral cavity cancer types. It requires early detection via various medical technologies to improve the survival rate. While most detection techniques for OSCC require testing in a centralized lab to confirm cancer type, a point of care detection technique is preferred for on-site use and quick result readout. The modular biological sensor utilizing transistor-based technology has been leveraged for testing CIP2A, and optimal transistor gate voltage and load resistance for sensing setup was investigated. Sensitivities of 1 × 10-15 g/ml have been obtained for both detections of pure CIP2A protein and HeLa cell lysate using identical test conditions via serial dilution. The superior time-saving and high accuracy testing provides opportunities for rapid clinical diagnosis in the medical space.

Original languageEnglish
Article number013201
JournalJournal of Vacuum Science and Technology B:Nanotechnology and Microelectronics
Volume41
Issue number1
DOIs
StatePublished - 1 Jan 2023

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