Hepatoprotection of noni juice against chronic alcohol consumption: Lipid homeostasis, antioxidation, alcohol clearance, and anti-inflammation

Yuan Yen Chang, Yi Ling Lin, Deng Jye Yang, Chen Wei Liu, Chin Lin Hsu, Bor Show Tzang, Yi Chen Chen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

Chronic alcohol consumption leads to steatohepatitis and cirrhosis. Naturally fermented noni juice (NJ) contains polyphenols, polysaccharides, and some trace minerals. This study explored protective effects of NJ against chronic alcohol consumption. Mice were assigned randomly to one of the following groups: (1) control, control liquid diet and distilled water; (2) alcohol, alcohol liquid diet and distilled water; (3) Alc+NJ-1X, alcohol liquid diet and 5 mL NJ/kg BW; (4) Alc+NJ-2X, alcohol liquid diet and 10 mL NJ/kg BW; (5) Alc+NJ-3X, alcohol and 15 mL NJ/kg BW for 4 weeks. NJ decreased (p < 0.05) serum AST, ALT, and alcohol levels and liver lipids, as well as increased (p < 0.05) daily fecal lipid outputs in alcohol-diet fed mice. NJ supplementation not only down-regulated (p < 0.05) lipogenesis but also up-regulated (p < 0.05) fatty acid β-oxidation in livers of alcohol-diet fed mice. NJ also accelerated alcohol clearance via increased (p < 0.05) hepatic ADH and ALDH activities. NJ increased (p < 0.05) hepatic TEAC and GSH levels but decreased (p < 0.05) TBARS value and TLR2/4, P38, ERK 1/2, NFκB P65, iNOS, COX-2, TNF-α, and IL-1β expressions in alcohol-diet fed mice. NJ promotes hepatoprotection against alcohol-induced injury due to regulations of lipid homeostasis, antioxidant status, alcohol metabolism, and anti-inflammatory responses.

Original languageEnglish
Pages (from-to)11016-11024
Number of pages9
JournalJournal of Agricultural and Food Chemistry
Volume61
Issue number46
DOIs
StatePublished - 20 Nov 2013

Keywords

  • alcohol metabolism
  • anti-inflammatory response
  • antioxidant capacity
  • lipid homeostasis
  • noni juice

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