Helicobacter pylori-negative low-grade extranodal B-cell primary gastric mucosa-associated lymphoid tissue lymphoma

Ying Ying Yang, Shu Shun Lo, Fen Yau Li, Han Chieh Lin*, Fa Yauh Lee, Full Young Chang, Shou Dong Lee

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Helicobacter pylori-negative primary mucosa-associated lymphoid tissue (MALT) lymphoma of the stomach - a primary gastric lymphoma (PGL) - is not very common. Herein, we report a 77-year-old man with the chief complaint of intermittent epigastric pain. Initial upper gastrointestinal (UGI) endoscopy showed multiple irregular ulcers (GUs) over the antrum with poor distention of the stomach, and gastric adenocarcinoma (Borrmann type IV, linitis plastica) was suspected. But the biopsy specimens of the GUs showed chronic inflammation without malignant change or H. pylori infection. Nevertheless, delayed healing of the GUs, specific endoscopic findings and enlarged paragastric lymph nodes on computed tomography of the abdomen alerted us to the possibility of PGL. After repeat UGI endoscopies, the patient was finally diagnosed with extranodal B-cell PGL. The patient received radical subtotal gastrectomy and Billroth II operation; the surgical margins were free of tumor cells. The patient was followed up in the outpatient department for 20 months, and his postoperative condition was good.

Original languageEnglish
Pages (from-to)121-125
Number of pages5
JournalJournal of the Chinese Medical Association
Issue number3
StatePublished - Mar 2007


  • Enlarged paragastric lymph nodes
  • Helicobacter pylori
  • Primary mucosa-associated lymphoid tissue gastric lymphoma


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