GSK3 modulation in acute lung injury, myocarditis and polycystic kidney disease-related aneurysm

Wei Lun Liu; Fu Tien Chiang; Juliana Tze Wah Kao; Shih Hwa Chiou; Heng Liang Lin

doi:10.1016/j.bbamcr.2020.118798

GSK3 modulation in acute lung injury, myocarditis and polycystic kidney disease-related aneurysm

Wei Lun Liu, Fu Tien Chiang, Juliana Tze Wah Kao, Shih Hwa Chiou, Heng Liang Lin^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

GSK3 are involved in different physical and pathological conditions and inflammatory regulated by macrophages contribute to significant mechanism. Infection stimuli may modulate GSK3 activity and influence host cell adaption, immune cells infiltration or cytokine expressions. To further address the role of GSK3 modulation in macrophages, the signal transduction of three major organs challenged by endotoxin, virus and genetic inherited factors are briefly introduced (lung injury, myocarditis and autosomal dominant polycystic kidney disease). As a result of pro-inflammatory and anti-inflammatory functions of GSK3 in different microenvironments and stages of macrophages (M1/M2), the rational resolution should be considered by adequately GSK3.

Original language	English
Article number	118798
Journal	Biochimica et Biophysica Acta - Molecular Cell Research
Volume	1867
Issue number	11
DOIs	https://doi.org/10.1016/j.bbamcr.2020.118798
State	Published - Nov 2020

Keywords

HMGB1/IL-17A/autophagy
M1/M2 macrophages
Mitotic catastrophe
PI3K/Akt/GSK3β/MCP-1 axis
Podocyte
Pulmonary edema

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title = "GSK3 modulation in acute lung injury, myocarditis and polycystic kidney disease-related aneurysm",

abstract = "GSK3 are involved in different physical and pathological conditions and inflammatory regulated by macrophages contribute to significant mechanism. Infection stimuli may modulate GSK3 activity and influence host cell adaption, immune cells infiltration or cytokine expressions. To further address the role of GSK3 modulation in macrophages, the signal transduction of three major organs challenged by endotoxin, virus and genetic inherited factors are briefly introduced (lung injury, myocarditis and autosomal dominant polycystic kidney disease). As a result of pro-inflammatory and anti-inflammatory functions of GSK3 in different microenvironments and stages of macrophages (M1/M2), the rational resolution should be considered by adequately GSK3.",

keywords = "HMGB1/IL-17A/autophagy, M1/M2 macrophages, Mitotic catastrophe, PI3K/Akt/GSK3β/MCP-1 axis, Podocyte, Pulmonary edema",

author = "Liu, {Wei Lun} and Chiang, {Fu Tien} and Kao, {Juliana Tze Wah} and Chiou, {Shih Hwa} and Lin, {Heng Liang}",

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year = "2020",

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doi = "10.1016/j.bbamcr.2020.118798",

language = "English",

volume = "1867",

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TY - JOUR

T1 - GSK3 modulation in acute lung injury, myocarditis and polycystic kidney disease-related aneurysm

AU - Liu, Wei Lun

AU - Chiang, Fu Tien

AU - Kao, Juliana Tze Wah

AU - Chiou, Shih Hwa

AU - Lin, Heng Liang

PY - 2020/11

Y1 - 2020/11

N2 - GSK3 are involved in different physical and pathological conditions and inflammatory regulated by macrophages contribute to significant mechanism. Infection stimuli may modulate GSK3 activity and influence host cell adaption, immune cells infiltration or cytokine expressions. To further address the role of GSK3 modulation in macrophages, the signal transduction of three major organs challenged by endotoxin, virus and genetic inherited factors are briefly introduced (lung injury, myocarditis and autosomal dominant polycystic kidney disease). As a result of pro-inflammatory and anti-inflammatory functions of GSK3 in different microenvironments and stages of macrophages (M1/M2), the rational resolution should be considered by adequately GSK3.

AB - GSK3 are involved in different physical and pathological conditions and inflammatory regulated by macrophages contribute to significant mechanism. Infection stimuli may modulate GSK3 activity and influence host cell adaption, immune cells infiltration or cytokine expressions. To further address the role of GSK3 modulation in macrophages, the signal transduction of three major organs challenged by endotoxin, virus and genetic inherited factors are briefly introduced (lung injury, myocarditis and autosomal dominant polycystic kidney disease). As a result of pro-inflammatory and anti-inflammatory functions of GSK3 in different microenvironments and stages of macrophages (M1/M2), the rational resolution should be considered by adequately GSK3.

KW - HMGB1/IL-17A/autophagy

KW - M1/M2 macrophages

KW - Mitotic catastrophe

KW - PI3K/Akt/GSK3β/MCP-1 axis

KW - Podocyte

KW - Pulmonary edema

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U2 - 10.1016/j.bbamcr.2020.118798

DO - 10.1016/j.bbamcr.2020.118798

M3 - Review article

C2 - 32693109

AN - SCOPUS:85089002201

SN - 0167-4889

VL - 1867

JO - Biochimica et Biophysica Acta - Molecular Cell Research

JF - Biochimica et Biophysica Acta - Molecular Cell Research

IS - 11

M1 - 118798

ER -

GSK3 modulation in acute lung injury, myocarditis and polycystic kidney disease-related aneurysm

Abstract

Keywords

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