Gradient Guided-Mode Resonance Biosensor with Smartphone Readout

Ting Zhou Lin, Cheng Hao Chen, Yuan Pei Lei, Cheng Sheng Huang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Integrating biosensors with smartphones is becoming an increasingly popular method for detecting various biomolecules and could replace expensive laboratory-based instruments. In this work, we demonstrate a novel smartphone-based biosensor system with a gradient grating period guided-mode resonance (GGP-GMR) sensor. The sensor comprises numerous gratings which each correspond to and block the light of a specific resonant wavelength. This results in a dark band, which is observed using a CCD underneath the GGP-GMR sensor. By monitoring the shift in the dark band, the concentration of a molecule in a sample can be determined. The sensor is illuminated by a light-emitting diode, and the light transmitted through the GGP-GMR sensor is directly captured by a smartphone, which then displays the results. Experiments were performed to validate the proposed smartphone biosensor and a limit of detection (LOD) of 1.50 × 10−3 RIU was achieved for sucrose solutions. Additionally, multiplexed detection was demonstrated for albumin and creatinine solutions at concentrations of 0–500 and 0–1 mg/mL, respectively; the corresponding LODs were 1.18 and 20.56 μg/mL.

Original languageEnglish
Article number1006
Issue number12
StatePublished - Dec 2023


  • albumin
  • creatinine
  • guided-mode resonance
  • optical biosensor
  • smartphone biosensor


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