Glycemia lowering effect of an aqueous extract of hedychium coronarium leaves in diabetic rodent models

Ling Shan Tse, Po Lin Liao, Chi Hao Tsai, Ching Hao Li, Jiunn Wang Liao, Jaw Jou Kang, Yu Wen Cheng*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Hedychium coronarium has a long history of use worldwide as a food and in folk medicine. In this study, we aimed to investigate the effect of an aqueous extract of H. coronarium leaves (HC) on type 2 diabetes mellitus (T2DM). Two types of animal models were used in this study: Streptozotocin (STZ)-induced T2DM (Wistar rats; N = 8) and C57BKSdb/db mice (N = 5). After treatment with HC for 28 days, glucose tolerance improved in both of the diabetic animal models. As significant effects were shown after 14 days of treatment in the STZ-induced T2DM model, we carried out the experiments with it. After 28 days of treatment with HC, the levels of cholesterol, triglyceride, high-density lipoprotein, and low-density lipoprotein were significantly improved in the STZ-induced T2DM model. The lesions degree of islet β-cells was decreased after the HC treatment. Although the insulin level increased moderately, the aldosterone level was significantly decreased in the HC-treated groups, suggesting that aldosterone might play an important role in this effect. In summary, HC is a natural product and it is worth exploring its effect on T2DM.

Original languageEnglish
Article number629
Issue number3
StatePublished - Mar 2019


  • Aldosterone
  • Folk medicine
  • Hedychium coronarium
  • Metabolic syndrome
  • Streptozotocin
  • Type 2 diabetes


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