Glucosamine Interferes With Myelopoiesis and Enhances the Immunosuppressive Activity of Myeloid-Derived Suppressor Cells

Eric Chang Yi Lin, Shuoh Wen Chen, Luen Kui Chen, Ting An Lin, Yu Xuan Wu, Chi Chang Juan, Yuan I. Chang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Glucosamine (GlcN) is the most widely consumed dietary supplement and exhibits anti-inflammatory effects. However, the influence of GlcN on immune cell generation and function is largely unclear. In this study, GlcN was delivered into mice to examine its biological function in hematopoiesis. We found that GlcN promoted the production of immature myeloid cells, known as myeloid-derived suppressor cells (MDSCs), both in vivo and in vitro. Additionally, GlcN upregulated the expression of glucose transporter 1 in hematopoietic stem and progenitor cells (HSPCs), influenced HSPC functions, and downregulated key genes involved in myelopoiesis. Furthermore, GlcN increased the expression of arginase 1 and inducible nitric oxide synthase to produce high levels of reactive oxygen species, which was regulated by the STAT3 and ERK1/2 pathways, to increase the immunosuppressive ability of MDSCs. We revealed a novel role for GlcN in myelopoiesis and MDSC activity involving a potential link between GlcN and immune system, as well as the new therapeutic benefit.

Original languageEnglish
Article number762363
JournalFrontiers in Nutrition
Volume8
DOIs
StatePublished - 10 Nov 2021

Keywords

  • d-Glucosamine hydrochloride (PubChem CID: 91431)
  • hematopoietic stem cell (HSC)
  • immunosuppression
  • myeloid-derived suppressive cell
  • myelopoiesis

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