Global longitudinal assessment of treatment outcomes in recurrent/metastatic nasopharyngeal carcinoma: GLANCE-NPC study

Myung Ju Ahn; Diana Chirovsky; Hélène Kuyas; Valérie Auclair; Saida Abounit; Seongjung Joo; Roshani Shah; Muh Hwa Yang

doi:10.2217/fon-2020-1087

Global longitudinal assessment of treatment outcomes in recurrent/metastatic nasopharyngeal carcinoma: GLANCE-NPC study

Myung Ju Ahn, Diana Chirovsky^*, Hélène Kuyas, Valérie Auclair, Saida Abounit, Seongjung Joo, Roshani Shah, Muh Hwa Yang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Aim: Given a lack of standard of care treatment for recurrent/metastatic nasopharyngeal carcinoma (R/M NPC), we assessed treatment patterns and overall survival in the real-world setting. Materials & methods: A retrospective chart review was conducted in patients who initiated first-line systemic therapy in Taiwan and South Korea between January 2012 and June 2013 with follow-up through December 2015. Results: Among 154 R/M NPC patients, all patients in Taiwan (n = 104) had distant metastases, whereas in South Korea (n = 50) 42% had distant metastases. Patients with distant metastases generally received systemic therapy only (71%) for whom median overall survival was 23 months (95% CI: 18-32). Conclusion: Prognosis in R/M NPC with distant metastases remains poor, underscoring the need for more efficacious treatments.

Original language	English
Pages (from-to)	2015-2025
Number of pages	11
Journal	Future Oncology
Volume	17
Issue number	16
DOIs	https://doi.org/10.2217/fon-2020-1087
State	Published - Jun 2021

Keywords

nasopharyngeal carcinoma
neoplasm metastasis
NPC
recurrent disease
South Korea
survival rate
Taiwan
treatment outcome

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2217/fon-2020-1087

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title = "Global longitudinal assessment of treatment outcomes in recurrent/metastatic nasopharyngeal carcinoma: GLANCE-NPC study",

abstract = "Aim: Given a lack of standard of care treatment for recurrent/metastatic nasopharyngeal carcinoma (R/M NPC), we assessed treatment patterns and overall survival in the real-world setting. Materials & methods: A retrospective chart review was conducted in patients who initiated first-line systemic therapy in Taiwan and South Korea between January 2012 and June 2013 with follow-up through December 2015. Results: Among 154 R/M NPC patients, all patients in Taiwan (n = 104) had distant metastases, whereas in South Korea (n = 50) 42% had distant metastases. Patients with distant metastases generally received systemic therapy only (71%) for whom median overall survival was 23 months (95% CI: 18-32). Conclusion: Prognosis in R/M NPC with distant metastases remains poor, underscoring the need for more efficacious treatments. ",

keywords = "nasopharyngeal carcinoma, neoplasm metastasis, NPC, recurrent disease, South Korea, survival rate, Taiwan, treatment outcome",

author = "Ahn, {Myung Ju} and Diana Chirovsky and H{\'e}l{\`e}ne Kuyas and Val{\'e}rie Auclair and Saida Abounit and Seongjung Joo and Roshani Shah and Yang, {Muh Hwa}",

year = "2021",

month = jun,

doi = "10.2217/fon-2020-1087",

language = "English",

volume = "17",

pages = "2015--2025",

journal = "Future Oncology",

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T1 - Global longitudinal assessment of treatment outcomes in recurrent/metastatic nasopharyngeal carcinoma

T2 - GLANCE-NPC study

AU - Ahn, Myung Ju

AU - Chirovsky, Diana

AU - Kuyas, Hélène

AU - Auclair, Valérie

AU - Abounit, Saida

AU - Joo, Seongjung

AU - Shah, Roshani

AU - Yang, Muh Hwa

PY - 2021/6

Y1 - 2021/6

N2 - Aim: Given a lack of standard of care treatment for recurrent/metastatic nasopharyngeal carcinoma (R/M NPC), we assessed treatment patterns and overall survival in the real-world setting. Materials & methods: A retrospective chart review was conducted in patients who initiated first-line systemic therapy in Taiwan and South Korea between January 2012 and June 2013 with follow-up through December 2015. Results: Among 154 R/M NPC patients, all patients in Taiwan (n = 104) had distant metastases, whereas in South Korea (n = 50) 42% had distant metastases. Patients with distant metastases generally received systemic therapy only (71%) for whom median overall survival was 23 months (95% CI: 18-32). Conclusion: Prognosis in R/M NPC with distant metastases remains poor, underscoring the need for more efficacious treatments.

AB - Aim: Given a lack of standard of care treatment for recurrent/metastatic nasopharyngeal carcinoma (R/M NPC), we assessed treatment patterns and overall survival in the real-world setting. Materials & methods: A retrospective chart review was conducted in patients who initiated first-line systemic therapy in Taiwan and South Korea between January 2012 and June 2013 with follow-up through December 2015. Results: Among 154 R/M NPC patients, all patients in Taiwan (n = 104) had distant metastases, whereas in South Korea (n = 50) 42% had distant metastases. Patients with distant metastases generally received systemic therapy only (71%) for whom median overall survival was 23 months (95% CI: 18-32). Conclusion: Prognosis in R/M NPC with distant metastases remains poor, underscoring the need for more efficacious treatments.

KW - nasopharyngeal carcinoma

KW - neoplasm metastasis

KW - NPC

KW - recurrent disease

KW - South Korea

KW - survival rate

KW - Taiwan

KW - treatment outcome

UR - http://www.scopus.com/inward/record.url?scp=85106920560&partnerID=8YFLogxK

U2 - 10.2217/fon-2020-1087

DO - 10.2217/fon-2020-1087

M3 - Article

C2 - 33601910

AN - SCOPUS:85106920560

SN - 1479-6694

VL - 17

SP - 2015

EP - 2025

JO - Future Oncology

JF - Future Oncology

IS - 16

ER -

Global longitudinal assessment of treatment outcomes in recurrent/metastatic nasopharyngeal carcinoma: GLANCE-NPC study

Abstract

Keywords

UN SDGs

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