Glaucoma, Alzheimer's disease, and Parkinson's disease: An 8-year population-based follow-up study

I. Chan Lin; Yuan Hung Wang; Tsung Jen Wang; I. Jong Wang; Yun Den Shen; Nai Fang Chi; Li Nien Chien

doi:10.1371/journal.pone.0108938

Glaucoma, Alzheimer's disease, and Parkinson's disease: An 8-year population-based follow-up study

I. Chan Lin^*, Yuan Hung Wang, Tsung Jen Wang, I. Jong Wang, Yun Den Shen, Nai Fang Chi, Li Nien Chien

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

74 Scopus citations

Abstract

Background: Glaucoma is the leading cause of irreversible blindness worldwide and primary open-angle glaucoma (POAG) is the most common type of glaucoma. An association between POAG and the subsequent risk of Alzheimer's disease (AD) and Parkinson's disease (PD) was unclear.

Objective: To investigate the association between POAG (including normal-tension glaucoma) and the subsequent risk of AD or PD 8 years following a diagnosis of POAG.

Methods: We performed a retrospective, propensity-score-matched analysis of a population-based cohort consisting of patients with and without POAG aged 60 years and older. Control patients without POAG were propensity-score matched to POAG patients based on their baseline characteristics.

Results: The incidence rates and confidence intervals (CIs) of AD among the patients with and without POAG were 2.85 (95% CI: 2.19-3.70) and 1.98 (95% CI: 1.68-2.31) per 1000 person-years, respectively. The incidence rates of PD among the POAG and non-POAG cohorts were 4.36 (95% CI: 3.52-5.39) and 4.37 (95% CI: 3.92-4.86) per 1000 person-years, respectively. Kaplan-Meier failure curves showed that the POAG patients had a higher risk of AD than the control patients did (log-rank test, P=.0189). However, the cumulative PD hazard ratios for the POAG and non-POAG patients did not differ significantly (log-rank test, P = .9953).

Conclusion: In elderly patients, POAG is a significant predictor of AD, but POAG is not a predictor of PD.

Original language	English
Article number	08938
Journal	PLoS ONE
Volume	9
Issue number	10
DOIs	https://doi.org/10.1371/journal.pone.0108938
State	Published - 2 Oct 2014

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title = "Glaucoma, Alzheimer's disease, and Parkinson's disease: An 8-year population-based follow-up study",

abstract = "Background: Glaucoma is the leading cause of irreversible blindness worldwide and primary open-angle glaucoma (POAG) is the most common type of glaucoma. An association between POAG and the subsequent risk of Alzheimer's disease (AD) and Parkinson's disease (PD) was unclear.Objective: To investigate the association between POAG (including normal-tension glaucoma) and the subsequent risk of AD or PD 8 years following a diagnosis of POAG.Methods: We performed a retrospective, propensity-score-matched analysis of a population-based cohort consisting of patients with and without POAG aged 60 years and older. Control patients without POAG were propensity-score matched to POAG patients based on their baseline characteristics.Results: The incidence rates and confidence intervals (CIs) of AD among the patients with and without POAG were 2.85 (95% CI: 2.19-3.70) and 1.98 (95% CI: 1.68-2.31) per 1000 person-years, respectively. The incidence rates of PD among the POAG and non-POAG cohorts were 4.36 (95% CI: 3.52-5.39) and 4.37 (95% CI: 3.92-4.86) per 1000 person-years, respectively. Kaplan-Meier failure curves showed that the POAG patients had a higher risk of AD than the control patients did (log-rank test, P=.0189). However, the cumulative PD hazard ratios for the POAG and non-POAG patients did not differ significantly (log-rank test, P = .9953).Conclusion: In elderly patients, POAG is a significant predictor of AD, but POAG is not a predictor of PD.",

author = "Lin, {I. Chan} and Wang, {Yuan Hung} and Wang, {Tsung Jen} and Wang, {I. Jong} and Shen, {Yun Den} and Chi, {Nai Fang} and Chien, {Li Nien}",

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T1 - Glaucoma, Alzheimer's disease, and Parkinson's disease

T2 - An 8-year population-based follow-up study

AU - Lin, I. Chan

AU - Wang, Yuan Hung

AU - Wang, Tsung Jen

AU - Wang, I. Jong

AU - Shen, Yun Den

AU - Chi, Nai Fang

AU - Chien, Li Nien

PY - 2014/10/2

Y1 - 2014/10/2

N2 - Background: Glaucoma is the leading cause of irreversible blindness worldwide and primary open-angle glaucoma (POAG) is the most common type of glaucoma. An association between POAG and the subsequent risk of Alzheimer's disease (AD) and Parkinson's disease (PD) was unclear.Objective: To investigate the association between POAG (including normal-tension glaucoma) and the subsequent risk of AD or PD 8 years following a diagnosis of POAG.Methods: We performed a retrospective, propensity-score-matched analysis of a population-based cohort consisting of patients with and without POAG aged 60 years and older. Control patients without POAG were propensity-score matched to POAG patients based on their baseline characteristics.Results: The incidence rates and confidence intervals (CIs) of AD among the patients with and without POAG were 2.85 (95% CI: 2.19-3.70) and 1.98 (95% CI: 1.68-2.31) per 1000 person-years, respectively. The incidence rates of PD among the POAG and non-POAG cohorts were 4.36 (95% CI: 3.52-5.39) and 4.37 (95% CI: 3.92-4.86) per 1000 person-years, respectively. Kaplan-Meier failure curves showed that the POAG patients had a higher risk of AD than the control patients did (log-rank test, P=.0189). However, the cumulative PD hazard ratios for the POAG and non-POAG patients did not differ significantly (log-rank test, P = .9953).Conclusion: In elderly patients, POAG is a significant predictor of AD, but POAG is not a predictor of PD.

AB - Background: Glaucoma is the leading cause of irreversible blindness worldwide and primary open-angle glaucoma (POAG) is the most common type of glaucoma. An association between POAG and the subsequent risk of Alzheimer's disease (AD) and Parkinson's disease (PD) was unclear.Objective: To investigate the association between POAG (including normal-tension glaucoma) and the subsequent risk of AD or PD 8 years following a diagnosis of POAG.Methods: We performed a retrospective, propensity-score-matched analysis of a population-based cohort consisting of patients with and without POAG aged 60 years and older. Control patients without POAG were propensity-score matched to POAG patients based on their baseline characteristics.Results: The incidence rates and confidence intervals (CIs) of AD among the patients with and without POAG were 2.85 (95% CI: 2.19-3.70) and 1.98 (95% CI: 1.68-2.31) per 1000 person-years, respectively. The incidence rates of PD among the POAG and non-POAG cohorts were 4.36 (95% CI: 3.52-5.39) and 4.37 (95% CI: 3.92-4.86) per 1000 person-years, respectively. Kaplan-Meier failure curves showed that the POAG patients had a higher risk of AD than the control patients did (log-rank test, P=.0189). However, the cumulative PD hazard ratios for the POAG and non-POAG patients did not differ significantly (log-rank test, P = .9953).Conclusion: In elderly patients, POAG is a significant predictor of AD, but POAG is not a predictor of PD.

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DO - 10.1371/journal.pone.0108938

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VL - 9

JO - PLoS ONE

JF - PLoS ONE

IS - 10

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ER -

Glaucoma, Alzheimer's disease, and Parkinson's disease: An 8-year population-based follow-up study

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