Giant Congenital Melanocytic Nevi in Neonates: Report of Two Cases

Jen Chung Chien, Dau Ming Niu*, Mao Shan Wang, Ming Tzen Liu, Jiing Feng Lirng, Shu Jen Chen, Betau Hwang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Giant congenital melanocytic nevi are rare, with an estimated incidence of approximately 1 in 20,000 live births. They increase the lifetime risk for malignant melanoma and neurological deficits, including leptomeningeal melanocytosis and epilepsy. Recently, we encountered two patients in whom giant congenital melanocytic nevi were noted at birth. Case 1 presented with the largest nevus spreading across the posterior scalp, neck, chest wall, shoulder and upper back. At the age of 2 months, magnetic resonance imaging (MRI) was performed and no leptomeningeal melanocytosis was found. Case 2 presented with a huge nevus covering most parts of the lower abdomen, lower back, buttocks and bilateral upper thighs. She also had normal MRI findings in the newborn period. At the age of 7 years, leptomeningeal thickening on the surface of the junction between the pons and midbrain was found on brain MRI although she was neurologically asymptomatic. Here, we describe these two cases with congenital melanocytic nevi and review the literature about its clinical manifestations, outcomes, risks for malignant melanoma and neurocutaneous melanosis, and possible surgical interventions.

Original languageEnglish
Pages (from-to)61-64
Number of pages4
JournalPediatrics and Neonatology
Volume51
Issue number1
DOIs
StatePublished - Feb 2010

Keywords

  • giant congenital
  • malignant melanoma
  • melanocytic nevi
  • neurocutaneous melanosis

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