Ghrelin, des-acyl ghrelin and obestatin on the gastrointestinal motility

Mineko Fujimiya; Koji Ataka; Akihiro Asakawa; Chih Yen Chen; Ikuo Kato; Akio Inui

doi:10.1016/j.peptides.2011.07.020

Ghrelin, des-acyl ghrelin and obestatin on the gastrointestinal motility

Mineko Fujimiya^*, Koji Ataka, Akihiro Asakawa, Chih Yen Chen, Ikuo Kato, Akio Inui

^*Corresponding author for this work

Department of Internal Medicine

Research output: Contribution to journal › Review article › peer-review

22 Scopus citations

Abstract

Ghrelin, des-acyl ghrelin and obestatin are derived from a common prohormone, preproghrelin by posttranslational processing, originating from endocrine cells in the stomach. Ghrelin exerts stimulatory effects on the motility of antrum and duodenum in both fed and fasted state of animals. On the other hand, des-acyl ghrelin exerts inhibitory effects on the motility of antrum but not on the motility of duodenum in the fasted state of animals. Obestatin exerts inhibitory effects on the motility of antrum and duodenum in the fed state but not in the fasted state of animals. NPY Y2 and Y4 receptors in the brain may mediate the action of ghrelin, CRF type 2 receptor in the brain may mediate the action of des-acyl ghrelin, whereas CRF type 1 and type 2 receptors in the brain may mediate the action of obestatin.

Original language	English
Pages (from-to)	2348-2351
Number of pages	4
Journal	Peptides
Volume	32
Issue number	11
DOIs	https://doi.org/10.1016/j.peptides.2011.07.020
State	Published - Nov 2011

Keywords

Des-acyl ghrelin
Gatrointestinal motility
Ghrelin
Hypothalamus
Obestatin

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10.1016/j.peptides.2011.07.020

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title = "Ghrelin, des-acyl ghrelin and obestatin on the gastrointestinal motility",

abstract = "Ghrelin, des-acyl ghrelin and obestatin are derived from a common prohormone, preproghrelin by posttranslational processing, originating from endocrine cells in the stomach. Ghrelin exerts stimulatory effects on the motility of antrum and duodenum in both fed and fasted state of animals. On the other hand, des-acyl ghrelin exerts inhibitory effects on the motility of antrum but not on the motility of duodenum in the fasted state of animals. Obestatin exerts inhibitory effects on the motility of antrum and duodenum in the fed state but not in the fasted state of animals. NPY Y2 and Y4 receptors in the brain may mediate the action of ghrelin, CRF type 2 receptor in the brain may mediate the action of des-acyl ghrelin, whereas CRF type 1 and type 2 receptors in the brain may mediate the action of obestatin.",

keywords = "Des-acyl ghrelin, Gatrointestinal motility, Ghrelin, Hypothalamus, Obestatin",

author = "Mineko Fujimiya and Koji Ataka and Akihiro Asakawa and Chen, {Chih Yen} and Ikuo Kato and Akio Inui",

year = "2011",

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doi = "10.1016/j.peptides.2011.07.020",

language = "English",

volume = "32",

pages = "2348--2351",

journal = "Peptides",

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T1 - Ghrelin, des-acyl ghrelin and obestatin on the gastrointestinal motility

AU - Fujimiya, Mineko

AU - Ataka, Koji

AU - Asakawa, Akihiro

AU - Chen, Chih Yen

AU - Kato, Ikuo

AU - Inui, Akio

PY - 2011/11

Y1 - 2011/11

N2 - Ghrelin, des-acyl ghrelin and obestatin are derived from a common prohormone, preproghrelin by posttranslational processing, originating from endocrine cells in the stomach. Ghrelin exerts stimulatory effects on the motility of antrum and duodenum in both fed and fasted state of animals. On the other hand, des-acyl ghrelin exerts inhibitory effects on the motility of antrum but not on the motility of duodenum in the fasted state of animals. Obestatin exerts inhibitory effects on the motility of antrum and duodenum in the fed state but not in the fasted state of animals. NPY Y2 and Y4 receptors in the brain may mediate the action of ghrelin, CRF type 2 receptor in the brain may mediate the action of des-acyl ghrelin, whereas CRF type 1 and type 2 receptors in the brain may mediate the action of obestatin.

AB - Ghrelin, des-acyl ghrelin and obestatin are derived from a common prohormone, preproghrelin by posttranslational processing, originating from endocrine cells in the stomach. Ghrelin exerts stimulatory effects on the motility of antrum and duodenum in both fed and fasted state of animals. On the other hand, des-acyl ghrelin exerts inhibitory effects on the motility of antrum but not on the motility of duodenum in the fasted state of animals. Obestatin exerts inhibitory effects on the motility of antrum and duodenum in the fed state but not in the fasted state of animals. NPY Y2 and Y4 receptors in the brain may mediate the action of ghrelin, CRF type 2 receptor in the brain may mediate the action of des-acyl ghrelin, whereas CRF type 1 and type 2 receptors in the brain may mediate the action of obestatin.

KW - Des-acyl ghrelin

KW - Gatrointestinal motility

KW - Ghrelin

KW - Hypothalamus

KW - Obestatin

UR - http://www.scopus.com/inward/record.url?scp=81755179395&partnerID=8YFLogxK

U2 - 10.1016/j.peptides.2011.07.020

DO - 10.1016/j.peptides.2011.07.020

M3 - Review article

C2 - 21835213

AN - SCOPUS:81755179395

SN - 0196-9781

VL - 32

SP - 2348

EP - 2351

JO - Peptides

JF - Peptides

IS - 11

ER -

Ghrelin, des-acyl ghrelin and obestatin on the gastrointestinal motility

Abstract

Keywords

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