Genome Mining of Micromonospora yangpuensis DSM 45577 as a Producer of an Anthraquinone-Fused Enediyne

Xiaohui Yan; Jian Jun Chen; Ajeeth Adhikari; Dong Yang; Ivana Crnovcic; Nan Wang; Chin-Yuan Chang; Christoph Rader; Ben Shen

doi:10.1021/acs.orglett.7b03120

Genome Mining of Micromonospora yangpuensis DSM 45577 as a Producer of an Anthraquinone-Fused Enediyne

Xiaohui Yan, Jian Jun Chen, Ajeeth Adhikari, Dong Yang, Ivana Crnovcic, Nan Wang, Chin-Yuan Chang, Christoph Rader, Ben Shen^*

^*Corresponding author for this work

Department of Biological Science and Technology

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

A new anthraquinone-fused enediyne, yangpumicin A (YPM A, 1), along with four Bergman cyclization congeners (YPM B-E, 2-5), was isolated from Micromonospora yangpuensis DSM 45577 after mining enediyne biosynthetic gene clusters from public actinobacterial genome databases and prioritizing the hits by an enediyne genome neighborhood network analysis for discovery. YPM A is potent against a broad spectrum of human cancer cell lines. The discovery of 1 provides new opportunities for the functionalization of enediynes to develop new conjugation chemistries for antibody-drug conjugates.

Original language	English
Pages (from-to)	6192-6195
Number of pages	4
Journal	Organic Letters
Volume	19
Issue number	22
DOIs	https://doi.org/10.1021/acs.orglett.7b03120
State	Published - 17 Nov 2017

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title = "Genome Mining of Micromonospora yangpuensis DSM 45577 as a Producer of an Anthraquinone-Fused Enediyne",

abstract = "A new anthraquinone-fused enediyne, yangpumicin A (YPM A, 1), along with four Bergman cyclization congeners (YPM B-E, 2-5), was isolated from Micromonospora yangpuensis DSM 45577 after mining enediyne biosynthetic gene clusters from public actinobacterial genome databases and prioritizing the hits by an enediyne genome neighborhood network analysis for discovery. YPM A is potent against a broad spectrum of human cancer cell lines. The discovery of 1 provides new opportunities for the functionalization of enediynes to develop new conjugation chemistries for antibody-drug conjugates.",

author = "Xiaohui Yan and Chen, {Jian Jun} and Ajeeth Adhikari and Dong Yang and Ivana Crnovcic and Nan Wang and Chin-Yuan Chang and Christoph Rader and Ben Shen",

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doi = "10.1021/acs.orglett.7b03120",

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T1 - Genome Mining of Micromonospora yangpuensis DSM 45577 as a Producer of an Anthraquinone-Fused Enediyne

AU - Yan, Xiaohui

AU - Chen, Jian Jun

AU - Adhikari, Ajeeth

AU - Yang, Dong

AU - Crnovcic, Ivana

AU - Wang, Nan

AU - Chang, Chin-Yuan

AU - Rader, Christoph

AU - Shen, Ben

PY - 2017/11/17

Y1 - 2017/11/17

N2 - A new anthraquinone-fused enediyne, yangpumicin A (YPM A, 1), along with four Bergman cyclization congeners (YPM B-E, 2-5), was isolated from Micromonospora yangpuensis DSM 45577 after mining enediyne biosynthetic gene clusters from public actinobacterial genome databases and prioritizing the hits by an enediyne genome neighborhood network analysis for discovery. YPM A is potent against a broad spectrum of human cancer cell lines. The discovery of 1 provides new opportunities for the functionalization of enediynes to develop new conjugation chemistries for antibody-drug conjugates.

AB - A new anthraquinone-fused enediyne, yangpumicin A (YPM A, 1), along with four Bergman cyclization congeners (YPM B-E, 2-5), was isolated from Micromonospora yangpuensis DSM 45577 after mining enediyne biosynthetic gene clusters from public actinobacterial genome databases and prioritizing the hits by an enediyne genome neighborhood network analysis for discovery. YPM A is potent against a broad spectrum of human cancer cell lines. The discovery of 1 provides new opportunities for the functionalization of enediynes to develop new conjugation chemistries for antibody-drug conjugates.

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DO - 10.1021/acs.orglett.7b03120

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SN - 1523-7060

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SP - 6192

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JO - Organic Letters

JF - Organic Letters

IS - 22

ER -

Genome Mining of Micromonospora yangpuensis DSM 45577 as a Producer of an Anthraquinone-Fused Enediyne

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