Genetic alterations in gastric cancer patients according to sex

Li Wen Hsu*, Kuo Hung Huang, Ming Huang Chen, Wen Liang Fang, Yee Chao, Su Shun Lo, Anna Fen Yau Li, Chew Wun Wu, Yi Ming Shyr

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

To date, few reports have investigated the genetic alterations and clinicopathological features in gastric cancer (GC) according to sex. In total, 2673 GC patients receiving curative surgery were enrolled. Among the 2673 GC patients, 1979 (74.0%) patients were male. After propensity-score matching, 846 patients were enrolled for the analysis, including 423 males and 423 females. There was no significant difference in the clinicopathological features between the sexes. Regarding the initial recurrence pattern, the males were more likely to develop tumor recurrence and liver metastasis than the females, especially in stage III GC. Regarding the molecular analysis, the males had higher PD-L1 expression than the females, especially in stage III GC. In addition, the patients aged ≥ 65 years had higher PD-L1 expression than the patients younger than 65 years. The multivariate analysis demonstrated that sex was among the independent prognostic factors affecting overall survival (OS) and disease-free survival (DFS). Among the patients with liver metastases, PD-L1 expression was more common among the aged male patients. The males were associated with more tumor recurrence and higher PD-L1 expression than the females, especially in stage III GC. For GC patients with liver metastases, PD-L1 testing is recommended, especially among aged male patients.

Original languageEnglish
Pages (from-to)376-388
Number of pages13
JournalAging
Volume13
Issue number1
DOIs
StatePublished - 15 Jan 2021

Keywords

  • clinicopathological feature
  • gastric cancer
  • genetic alteration
  • prognosis
  • sex

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