Generation of IBMS-iPSC-021, -022, -023 human induced pluripotent stem cells (IBMSi016-A, IBMSi017-A, and IBMSi018-A) derived from patients with the ALDH2 rs671 polymorphism

Ming Heng Tsai; Yueh Ting Chiu; Darien Zhing Herr Chan; Cheng Hao Wen; Shih Han Syu; Huai En Lu; Chi Ying F. Huang; Yenn Jiang Lin; Shih Lin Chang; Li Wei Lo; Ching Ying Huang; Yu Feng Hu; Patrick C.H. Hsieh; Shih Ann Chen

doi:10.1016/j.scr.2021.102416

Generation of IBMS-iPSC-021, -022, -023 human induced pluripotent stem cells (IBMSi016-A, IBMSi017-A, and IBMSi018-A) derived from patients with the ALDH2 rs671 polymorphism

Ming Heng Tsai, Yueh Ting Chiu, Darien Zhing Herr Chan, Cheng Hao Wen, Shih Han Syu, Huai En Lu, Chi Ying F. Huang, Yenn Jiang Lin, Shih Lin Chang, Li Wei Lo, Ching Ying Huang, Yu Feng Hu^*, Patrick C.H. Hsieh, Shih Ann Chen

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

ALDH2 gene is coded for the aldehyde dehydrogenase (ALDH), which is an enzyme involved in alcohol metabolism. Compared to normal aldehyde dehydrogenases, a homozygous point mutation on exon 12 from G to A significantly reduces its efficiency. In this study, we have reported the generation of IBMS-iPSC-021-04, IBMS-iPSC-022-01, and IBMS-iPSC-023-03 as induced pluripotent stem cell (iPSC) lines carrying the homozygous form of ALDH2 with the rs671 genetic polymorphism (E487K mutation). These cell lines were characterized in terms of pluripotency and differentiation potential. They serve as useful platforms to study alcohol metabolism and other chronic diseases associated with alcohol consumption.

Original language	English
Article number	102416
Journal	Stem Cell Research
Volume	54
DOIs	https://doi.org/10.1016/j.scr.2021.102416
State	Published - Jul 2021

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Tsai, M. H., Chiu, Y. T., Chan, D. Z. H., Wen, C. H., Syu, S. H., Lu, H. E., Huang, C. Y. F., Lin, Y. J., Chang, S. L., Lo, L. W., Huang, C. Y., Hu, Y. F., Hsieh, P. C. H., & Chen, S. A. (2021). Generation of IBMS-iPSC-021, -022, -023 human induced pluripotent stem cells (IBMSi016-A, IBMSi017-A, and IBMSi018-A) derived from patients with the ALDH2 rs671 polymorphism. Stem Cell Research, 54, Article 102416. https://doi.org/10.1016/j.scr.2021.102416

@article{4c1325e057254901949d6f934c4ed03f,

title = "Generation of IBMS-iPSC-021, -022, -023 human induced pluripotent stem cells (IBMSi016-A, IBMSi017-A, and IBMSi018-A) derived from patients with the ALDH2 rs671 polymorphism",

abstract = "ALDH2 gene is coded for the aldehyde dehydrogenase (ALDH), which is an enzyme involved in alcohol metabolism. Compared to normal aldehyde dehydrogenases, a homozygous point mutation on exon 12 from G to A significantly reduces its efficiency. In this study, we have reported the generation of IBMS-iPSC-021-04, IBMS-iPSC-022-01, and IBMS-iPSC-023-03 as induced pluripotent stem cell (iPSC) lines carrying the homozygous form of ALDH2 with the rs671 genetic polymorphism (E487K mutation). These cell lines were characterized in terms of pluripotency and differentiation potential. They serve as useful platforms to study alcohol metabolism and other chronic diseases associated with alcohol consumption.",

author = "Tsai, {Ming Heng} and Chiu, {Yueh Ting} and Chan, {Darien Zhing Herr} and Wen, {Cheng Hao} and Syu, {Shih Han} and Lu, {Huai En} and Huang, {Chi Ying F.} and Lin, {Yenn Jiang} and Chang, {Shih Lin} and Lo, {Li Wei} and Huang, {Ching Ying} and Hu, {Yu Feng} and Hsieh, {Patrick C.H.} and Chen, {Shih Ann}",

note = "Publisher Copyright: {\textcopyright} 2021 The Author(s)",

year = "2021",

month = jul,

doi = "10.1016/j.scr.2021.102416",

language = "English",

volume = "54",

journal = "Stem Cell Research",

issn = "1873-5061",

publisher = "Elsevier",

}

Tsai, MH, Chiu, YT, Chan, DZH, Wen, CH, Syu, SH, Lu, HE, Huang, CYF , Lin, YJ , Chang, SL , Lo, LW, Huang, CY, Hu, YF, Hsieh, PCH & Chen, SA 2021, 'Generation of IBMS-iPSC-021, -022, -023 human induced pluripotent stem cells (IBMSi016-A, IBMSi017-A, and IBMSi018-A) derived from patients with the ALDH2 rs671 polymorphism', Stem Cell Research, vol. 54, 102416. https://doi.org/10.1016/j.scr.2021.102416

TY - JOUR

T1 - Generation of IBMS-iPSC-021, -022, -023 human induced pluripotent stem cells (IBMSi016-A, IBMSi017-A, and IBMSi018-A) derived from patients with the ALDH2 rs671 polymorphism

AU - Tsai, Ming Heng

AU - Chiu, Yueh Ting

AU - Chan, Darien Zhing Herr

AU - Wen, Cheng Hao

AU - Syu, Shih Han

AU - Lu, Huai En

AU - Huang, Chi Ying F.

AU - Lin, Yenn Jiang

AU - Chang, Shih Lin

AU - Lo, Li Wei

AU - Huang, Ching Ying

AU - Hu, Yu Feng

AU - Hsieh, Patrick C.H.

AU - Chen, Shih Ann

PY - 2021/7

Y1 - 2021/7

N2 - ALDH2 gene is coded for the aldehyde dehydrogenase (ALDH), which is an enzyme involved in alcohol metabolism. Compared to normal aldehyde dehydrogenases, a homozygous point mutation on exon 12 from G to A significantly reduces its efficiency. In this study, we have reported the generation of IBMS-iPSC-021-04, IBMS-iPSC-022-01, and IBMS-iPSC-023-03 as induced pluripotent stem cell (iPSC) lines carrying the homozygous form of ALDH2 with the rs671 genetic polymorphism (E487K mutation). These cell lines were characterized in terms of pluripotency and differentiation potential. They serve as useful platforms to study alcohol metabolism and other chronic diseases associated with alcohol consumption.

AB - ALDH2 gene is coded for the aldehyde dehydrogenase (ALDH), which is an enzyme involved in alcohol metabolism. Compared to normal aldehyde dehydrogenases, a homozygous point mutation on exon 12 from G to A significantly reduces its efficiency. In this study, we have reported the generation of IBMS-iPSC-021-04, IBMS-iPSC-022-01, and IBMS-iPSC-023-03 as induced pluripotent stem cell (iPSC) lines carrying the homozygous form of ALDH2 with the rs671 genetic polymorphism (E487K mutation). These cell lines were characterized in terms of pluripotency and differentiation potential. They serve as useful platforms to study alcohol metabolism and other chronic diseases associated with alcohol consumption.

UR - http://www.scopus.com/inward/record.url?scp=85107621594&partnerID=8YFLogxK

U2 - 10.1016/j.scr.2021.102416

DO - 10.1016/j.scr.2021.102416

M3 - Article

C2 - 34118567

AN - SCOPUS:85107621594

SN - 1873-5061

VL - 54

JO - Stem Cell Research

JF - Stem Cell Research

M1 - 102416

ER -

Generation of IBMS-iPSC-021, -022, -023 human induced pluripotent stem cells (IBMSi016-A, IBMSi017-A, and IBMSi018-A) derived from patients with the ALDH2 rs671 polymorphism

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