Generation and cycloaddition of polymer-supported azomethine imines: Traceless synthesis of pyrazole derivatives from α-silylnitrosoamide derivatives bound to resin

Ken Ichi Washizuka, Keiko Nagai, Satoshi Minakata, Ilhyong Ryu, Mitsuo Komatsu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

1,3-Dipolar cycloaddition of polymer-supported azomethine imines with dimethyl acetylenedicarboxylate (DMAD) gave pyrazole derivatives in good yields. The azomethine imines were generated from polymer-supported α- silylnitrosoamides by a 1,4-silatropic shift. The feature of this reaction is that no cleavage operations are required after the cycloaddition. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)691-695
Number of pages5
JournalTetrahedron Letters
Volume41
Issue number5
DOIs
StatePublished - 29 Jan 2000

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