Gene therapy strategies for hepatocellular carcinoma

Lih Hwa Hwang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Hepatocellular carcinoma (HCC) is one of the most frequent cancers worldwide. Effective therapy to this cancer is currently lacking, creating an urgent need for new therapeutic strategies for HCC. Gene therapy approach that relies on the transduction of cells with genetic materials, such as apoptotic genes, suicide genes, genes coding for antiangiogenic factors or immunomodulatory molecules, small interfering RNA (siRNA), or oncolytic viral vectors, may provide a promising strategy. The aforementioned strategies have been largely evaluated in the animal models with HCC or liver metastasis. Due to the diversity of vectors and therapeutic genes, being used alone or in combination, gene therapy approach may generate great beneficial effects to control the growth of tumors within the liver.

Original languageEnglish
Pages (from-to)453-468
Number of pages16
JournalJournal of Biomedical Science
Issue number4
StatePublished - Jul 2006


  • Antiangiogenic factor
  • Apoptotic gene
  • Gene therapy
  • Hepatocellular carcinoma
  • Immunotherapy
  • Oncolytic virus
  • Suicide gene
  • siRNA


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