[Gd(DTPA-BDMA)] as a magnetic resonance contrast agent: Acute toxicity test and preliminary images

Reu Sheng Sheu, Yun-Ming Wang, Yu Ting Kuo, Tsann Hwang Cheng, Twei Shiun Jaw, Gin Chung Liu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The new complex of Gd(III) with the 1,7-bis[(N-dimethyl(carbomoyl) methyl)-1,4,7-triazaheptane-1,4,7-triacetate [Gd(DTPA-BDMA)] is a non-ionic paramagnetic complex designed for use as an extracellular magnetic resonance imaging (MRI) contrast agent. The R1 relaxivity value of [Gd(DTPA-BDMA)] is 4.13 ± 0.2 mM-1S-1, which is similar to that of [Gd(DTPA)]2- (4.08 mM-1S-1). The purpose of this study is to examine the acute toxicity and MRI characteristics of [Gd(DTPA-BDMA)]. Our results show that the lethal dose (LD50) of the [Gd (DTPA-BDMA)] is 10.58 mmol/kg in ICR mice, which is higher than that of [Gd (DTPA)]2-(6.40 mmol/kg). The MR images demonstrate that the enhancing effect and renal clearance of [Gd(DTPA-BDMA)] are similar to that of [Gd(DTPA)]2- either in control group or CHA (Cheng hepatoma ascites) tumor model in Wistar rats (p>0.05). These findings indicate that [(DTPA-BDMA)] has similar characteristics of [Gd(DTPA)]2- and has the potential of becoming a safe and reliable magnetopharmaceutical for the extracellular MRI contrast agent.

Original languageEnglish
Pages (from-to)77-83
Number of pages7
JournalKaohsiung Journal of Medical Sciences
Volume18
Issue number2
DOIs
StatePublished - 5 Jun 2002

Keywords

  • [Gd(DTPA-BDMA)]
  • Contrast media
  • Magnetic resonance imaging

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