Gastrointestinal and liver manifestations in patients with COVID-19

I. Cheng Lee, Teh Ia Huo*, Yi Hsiang Huang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

145 Scopus citations


As the outbreak of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly spread over the world, the World Health Organization has declared the outbreak of COVID-19 an international public health emergency. Besides typical respiratory symptoms and signs of COVID-19, digestive symptoms and liver injury have been frequently reported during the course of the disease. In this review, we summarized the recent studies reporting of gastrointestinal and liver manifestations during the course of COVID-19. Digestive symptoms, including anorexia, nausea, vomiting, and diarrhea, are not uncommon in patients with COVID-19, and in some cases digestive symptoms may occur in the absence of any respiratory symptoms. Furthermore, SARS-CoV-2 could be detected in the stool of infected patients, implicating the possibility of fecal–oral transmission. Attention should also be paid to monitor liver function during the course of COVID-19, especially in patients with higher disease severity.

Original languageEnglish
Pages (from-to)521-523
Number of pages3
JournalJournal of the Chinese Medical Association
Issue number6
StatePublished - Jun 2020


  • COVID-19
  • Digestive
  • Gastrointestinal
  • Liver
  • Severe acute respiratory syndrome coronavirus 2


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