TY - JOUR
T1 - GABAergic neuron death in the striatum following kainate-induced damage of hippocampal neurons
T2 - Evidence for the role of no in locomotion
AU - Shih, Yang Hsin
AU - Lee, Ai Wei
AU - Huang, Yn Ho
AU - Ko, Miau Hwa
AU - Fu, Yu Show
N1 - Funding Information:
Received 21 October 2003. This work was supported by Grants NSC 89-2314-B010-025 and NSC 89-2314-B-075-048 from the National Science Council, Grants Cl-92-3-1 and Cl-92-3-2 from Yen Tjing Ling Medical Foundation and CMC91-M-31 from China Medical University, Taiwan. Address correspondence to Yu-Show Fu, Department of Anatomy, School of Medicine, National Yang-Ming University, No. 155, Sec. 2, Li-Nung Street, Taipei, Taiwan, 112, R.O.C. E-mail: [email protected]
PY - 2004/9
Y1 - 2004/9
N2 - The authors examined the role of nitric oxide (NO) in the relationship between kainate-induced neuronal death and locomotion changes. Locomotion was significantly increased 1 h after kainate injection, suggesting that kainate induced NO and dopamine release. Cell death occurred in the CA1 (41%) and CA3 (54%) regions at 12 h. At 7 days, GABAergic neurons in striatum were lost, suggesting possible pyramidal neuron synapse with striatal GABAergic neurons, and pyramidal neuron damage leading to deafferentation and degeneration of striatal GABAergic neurons. Pre-administration of Nw-nitro-L- arginine-methyl-ester or 7-nitroindazole reduced these effects. These results indicate that NO may modulate kainate-induced neuronal death and locomotion.
AB - The authors examined the role of nitric oxide (NO) in the relationship between kainate-induced neuronal death and locomotion changes. Locomotion was significantly increased 1 h after kainate injection, suggesting that kainate induced NO and dopamine release. Cell death occurred in the CA1 (41%) and CA3 (54%) regions at 12 h. At 7 days, GABAergic neurons in striatum were lost, suggesting possible pyramidal neuron synapse with striatal GABAergic neurons, and pyramidal neuron damage leading to deafferentation and degeneration of striatal GABAergic neurons. Pre-administration of Nw-nitro-L- arginine-methyl-ester or 7-nitroindazole reduced these effects. These results indicate that NO may modulate kainate-induced neuronal death and locomotion.
KW - 7-nitroindazole
KW - Kainate
KW - Locomotion
KW - N-nitro-L- arginine methyl ester
KW - NO
KW - Neuronal death
UR - http://www.scopus.com/inward/record.url?scp=4444341173&partnerID=8YFLogxK
U2 - 10.1080/00207450490475616
DO - 10.1080/00207450490475616
M3 - Article
C2 - 15370178
AN - SCOPUS:4444341173
SN - 0020-7454
VL - 114
SP - 1119
EP - 1132
JO - International Journal of Neuroscience
JF - International Journal of Neuroscience
IS - 9
ER -